Impact of Single Dose Praziquantel Treatment on Schistosoma haematobium Infection among School Children in an Endemic Nigerian Community

Babatunde Adewale; Margaret A. Mafe; Medinat A. Sulyman; Emmanuel T. Idowu; Morakinyo B. Ajayi; David O. Akande; James H. Mckerrow; Emmanuel O. Balogun

추천

검색

질문

자료유형: 학술저널

저자정보: Babatunde Adewale (Nigerian Institute of Medical Research) Margaret A. Mafe (Nigerian Institute of Medical Research) Medinat A. Sulyman (Nigerian Institute of Medical Research) Emmanuel T. Idowu (University of Lagos) Morakinyo B. Ajayi (Nigerian Institute of Medical Research) David O. Akande (Nigerian Institute of Medical Research) James H. Mckerrow (University of California San Diego) Emmanuel O. Balogun (Ahmadu Bello University)

저널정보: 대한기생충학열대의학회 Parasites, Hosts and Diseases The Korean Journal of Parasitology Vol.56 No.6

발행연도: 2018.12

수록면: 577 - 581 (5page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Schistosomiasis is prevalent in Nigeria, and the foremost pathogen is Schistosoma haematobium, which affects about 29 million people. Single dose of the drug praziquantel is often recommended for treatment but the efficacy has not been documented in certain regions. Therefore, this study was designed to assess the impact of single dose praziquantel treatment on S. haematobium infection among school children in an endemic community of South-Western Nigeria. Urine samples were collected from 434 school children and 10 ml was filtered through Nucleopore filter paper before examination for egg outputs by microscopy. The prevalence was 24.9% at pre-treatment. There was no statistically significant difference for the prevalence of infection between males (14.7%) and females (10.2%), although the mean egg count for the females (9.87) was significantly more (P<0.05) than the males (6.06). At 6 and 12 months post-treatment there was 74.4% and 86.4% reduction in the mean egg count, respectively. Interestingly, an increased prevalence of infection from 2.1% at 6 months to 7.7% at 12 months post-treatment was observed, nonetheless the mean egg count was reduced to 0.27 at 12th month from 1.98 at 6 months post-treatment. Resurgence in the prevalence rate between 6 and 12 months post-treatment with praziquantel is herein reported and the need for a follow-up treatment in endemic areas for adequate impact on schistosomiasis control is discussed.

#Schistosoma haematobium #school #children #praziquantel

참고문헌 (26)

참고문헌 신청

[학술지(정기간행물)] - Cowper SG. / 1963 / Schistosomiasis in Nigeria / Ann Trop Med Parasitol 57 : 307 ~ 322

[학술지(정기간행물)] - Colley DG / 2014 / Human schistosomiasis / Lancet 383 : 2253 ~ 2264

[학술지(정기간행물)] - Steinmann P / 2006 / Schistosomiasis and water resources development: systematic review, metaanalysis, and estimates of people at risk / Lancet Infect Dis 6 : 411 ~ 425

[학술지(정기간행물)] - TchuemTchuenté L / 2017 / Moving from control to elimination of schistosomiasis in sub-Saharan Africa: time to change and adapt strategies / Infect Dis Poverty 6 : 42 ~

[학술지(정기간행물)] - Molyneux DH / 2017 / Neglected tropical diseases:progress towards addressing the chronic pandemic / Lancet 389 : 312 ~ 325

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!