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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.8
- 수록면
- 413 - 419 (7page)
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초록· 키워드
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The present study determined and compared the genetic diversity of Plasmodium falciparum strains infecting children living in 2 areas from Gabon with different malaria endemicity. Blood samples were collected from febrile children from 2008 to 2009 in 2 health centres from rural (Oyem) and urban (Owendo) areas. Genetic diversity was determined in P. falciparum isolates by analyzing the merozoite surface protein-1 (msp1) gene polymorphism using nested-PCR. Overall, 168 children with mild falciparum malaria were included. K1, Ro33, and Mad20 alleles were found in 110 (65.5%), 94 (55.9%), and 35 (20.8%) isolates, respectively, without difference according to the site (P>0.05). Allelic families’ frequencies were comparable between children less than 5 years old from the 2 sites; while among the older children the proportions of Ro33 and Mad20 alleles were 1.7 to 2.0 fold higher at Oyem. Thirty-three different alleles were detected, 16 (48.5%) were common to both sites, and 10 out of the 17 specific alleles were found at Oyem. Furthermore, multiple infection carriers were frequent at Oyem (57.7% vs 42.2% at Owendo; P=0.04) where the complexity of infection was of 1.88 (±0.95) higher compared to that found at Owendo (1.55±0.75). Extended genetic diversity of P. falciparum strains infecting Gabonese symptomatic children and high multiplicity of infections were observed in rural area. Alleles common to the 2 sites were frequent; the site-specific alleles predominated in the rural area. Such distribution of the alleles should be taken into accounts when designing MSP1 or MSP2 malaria vaccine.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (33)
참고문헌 신청
[보고서] - World Health Organization / 2013 / World Malaria Report 2013
[학술지(정기간행물)] - Paul RE / 1998 / Transmission intensity and Plasmodium falciparum diversity on the northwestern border of Thailand / Am J Trop Med Hyg 58 : 195 ~ 203
[학술지(정기간행물)] - Baruah S / 2009 / Temporal and spatial variation in MSP1 clonal composition of Plasmodium falciparum in districts of Assam, Northeast India / Infect Genet Evol 9 : 853 ~ 859
[학술지(정기간행물)] - Wanji S / 2012 / Genetic diversity of Plasmodium falciparum merozoite surface protein-1 block 2 in sites of contrasting altitudes and malaria endemicities in the Mount Cameroon region / Am J Trop Med Hyg 86 : 764 ~ 774
[학술지(정기간행물)] - Takala SL / 2006 / Genetic diversity in the Block 2 region of the merozoite surface protein 1 (MSP1) of Plasmodium falciparum: additional complexity and selection and convergence in fragment size polymorphism / Infect Genet Evol 6 : 417 ~ 424
[학술지(정기간행물)] - Paul RE / 1998 / Transmission intensity and Plasmodium falciparum diversity on the northwestern border of Thailand / Am J Trop Med Hyg 58 : 195 ~ 203
[학술지(정기간행물)] - Baruah S / 2009 / Temporal and spatial variation in MSP1 clonal composition of Plasmodium falciparum in districts of Assam, Northeast India / Infect Genet Evol 9 : 853 ~ 859
[학술지(정기간행물)] - Wanji S / 2012 / Genetic diversity of Plasmodium falciparum merozoite surface protein-1 block 2 in sites of contrasting altitudes and malaria endemicities in the Mount Cameroon region / Am J Trop Med Hyg 86 : 764 ~ 774
[학술지(정기간행물)] - Takala SL / 2006 / Genetic diversity in the Block 2 region of the merozoite surface protein 1 (MSP1) of Plasmodium falciparum: additional complexity and selection and convergence in fragment size polymorphism / Infect Genet Evol 6 : 417 ~ 424
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UCI(KEPA) : I410-ECN-0101-2016-513-001839459