Diagnostic Performance of Three Rapid Diagnostic Test Kits for Malaria Parasite Plasmodium falciparum

Seo Hye Park; Seung Jegal; Seong Kyu Ahn; Haneul Jung; Jinyoung Lee; Byoung-Kuk Na; Sung-Jong Hong; Young Yil Bahk; Tong-Soo Kim

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자료유형: 학술저널

저자정보: Seo Hye Park (Inha University School of Medicine) Seung Jegal (Incheon Metropolitan City Institute of Public Health and Environment) Seong Kyu Ahn (Inha University School of Medicine) Haneul Jung (Inha University School of Medicine) Jinyoung Lee (Inha University School of Medicine) Byoung-Kuk Na (Gyeongsang National University School of Medicine) Sung-Jong Hong (Chung-Ang University College of Medicine) Young Yil Bahk (Konkuk University) Tong-Soo Kim (Inha University School of Medicine)

저널정보: 대한기생충학열대의학회 Parasites, Hosts and Diseases The Korean Journal of Parasitology Vol.58 No.2

발행연도: 2020.4

수록면: 147 - 152 (6page)

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Malaria is a potent burden on public healthcare worldwide due to requiring rapid diagnosis and treatment. Nowadays, prompt diagnosis with rapid diagnostic tests (RDTs) has been widely accepted as an effective diagnostic technique in malaria-endemic countries, primarily due to their easy operation, fast output, and straightforward interpretation. The global availability and use of RDTs have gradually grown over recent decades as field-applicable diagnostic tests for the reliable confirmation of malaria infection and proper case management. This study was conducted to evaluate diagnostic performance of 3 commercially available malaria RDT kits : BIOCREDITTM Malaria Ag Pf(pLDH), Malaria Ag Pf(pLDH/pHRPII), and Malaria Ag Pf/Pv(pLDH/pLDH) (where pLDH and pHRPII stand for plasmodium lactate dehydrogenase and histidine-rich protein 2, respectively) for the specific detection of Plasmodium falciparum. A total of 1,129 blood samples including 95 blood samples, confirmed as vivax malaria infection by microscopic examinations and a nested-PCR method, were tested for falciparum malaria infection. The overall sensitivity and specificity of Malaria Ag Pf(pLDH/pHRPII), Malaria Ag Pf/Pv(pLDH/pLDH), and Pf(pLDH) for P. falciparum were 99.0% and 100%, 95.8% and 100%, and 100% and 100%, respectively. It is proposed that the 3 RDT kits perform reliable level of diagnostic accuracy of detection for P. falciparum parasites.

#Plasmodium falciparum #malaria #rapid diagnostic test #diagnostic performance

참고문헌 (35)

참고문헌 신청

Centers for Disease Control and Prevention / The History of Malaria, An Ancient Disease

Singh B / 2013 / Human infections and detection of Plasmodium knowlesi / Clin Microbiol Rev 26:165~184

Rubio JM / 2001 / Limited level of accuracy provided by available rapid diagnosis tests for malaria enhances the need for PCR-based reference laboratories / J Clin Microbiol 39:2736~2737

World Health Organization / 1999 / Malaria Diagnosis New Perspectives: Report of the Joint WHO/USAID Informal Consultation / World Health Organization

Casalino E / 2002 / Predictive factors of malaria in travelers to areas where malaria is endemic / Arch Intern Med 162:1625~1630

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