Sensitivity of Plasmodium falciparum to Antimalarial Drugs in Hainan Island, China

Shan-Qing Wang; Guang-Ze Wang; Yu-Chun Li; Feng Meng; Shi-Gan Lin; Zhen-Hu Zhu; Ding-Wei Sun; Chang-Hua He; Xi-Min Hu; Jian-Wei Du

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자료유형: 학술저널

저자정보: Shan-Qing Wang (Hainan Provincial Center for Disease Control and Prevention) Guang-Ze Wang (Hainan Provincial Center for Disease Control and Prevention) Yu-Chun Li (Hainan Provincial Center for Disease Control and Prevention) Feng Meng (Hainan Provincial Center for Disease Control and Prevention) Shi-Gan Lin (Hainan Provincial Center for Disease Control and Prevention) Zhen-Hu Zhu (Haikou Center for Disease Control and Prevention) Ding-Wei Sun (Hainan Provincial Center for Disease Control and Prevention) Chang-Hua He (Hainan Provincial Center for Disease Control and Prevention) Xi-Min Hu (Hainan Provincial Center for Disease Control and Prevention) Jian-Wei Du (Hainan Provincial Center for Disease Control and Prevention)

저널정보: 대한기생충학열대의학회 Parasites, Hosts and Diseases The Korean Journal of Parasitology Vol.53 No.1

발행연도: 2015.2

수록면: 35 - 41 (7page)

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Pyronaridine and artesunate have been shown to be effective in falciparum malaria treatment. However, pyronaridine is rarely used in Hainan Island clinically, and artesunate is not widely used as a therapeutic agent. Instead, conventional antimalarial drugs, chloroquine and piperaquine, are used, explaining the emergence of chloroquine-resistant Plasmodium falciparum. In this article, we investigated the sensitivity of P. falciparum to antimalarial drugs used in Hainan Island for rational drug therapy. We performed in vivo (28 days) and in vitro tests to determine the sensitivity of P. falciparum to antimalarial drugs. Total 46 patients with falciparum malaria were treated with dihydroartemisinin/piperaquine phosphate (DUOCOTECXIN) and followed up for 28 day. The cure rate was 97.8%. The mean fever clearance time (22.5±10.6 hr) and the mean parasite clearance time (27.3±12.2 hr) showed no statistical significance with different genders, ages, temperatures, or parasite density (P>0.05). The resistance rates of chloroquine, piperaquine, pyronarididine, and artesunate detected in vitro were 71.9%, 40.6%, 12.5%, and 0%, respectively (P<0.0001). The resistance intensities decreased as follows: chloroquine>piperaquine>pyronarididine>artesunate. The inhibitory dose 50 (IC50) was 3.77×10-6 mol/L, 2.09×10-6 mol/L, 0.09×10-6 mol/L, and 0.05×10-6 mol/L, and the mean concentrations for complete inhibition (CIMC) of schizont formation were 5.60×10-6 mol/L, 9.26×10-6 mol/L, 0.55×10-6 mol/L, and 0.07×10-6 mol/L, respectively. Dihydroartemisinin showed a strong therapeutic effect against falciparum malaria with a low toxicity.

#Plasmodium falciparum #antimalarial #sensitivity #in vivo and in vitro test

참고문헌 (25)

참고문헌 신청

Department of Endemic Disease, Ministry of Health / 1988 / Manual for malaria control. Beijing, China / People’s Medical Publishing House :163

Waki S / 1989 / A field trial of a fluorometric in vitro drug sensitivity test for Plasmodium falciparum in Hainan Island / Trans R Soc Trop Med Hyg 83:165~166

Chen L / 1998 / Changes of prevalence of drug-resistant falciparum malaria in Hainan Province, China / Guangzhou Uni Trad Chin Med 15:35~38

Zhou MX / 1979 / Report of two chloroquine-resistant falciparum malaria cases in Hainan Island / Med J Chin PLA 4:125

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