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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Background: The recent expansion of knowledge about various ABO alleles has led to the need for a comprehensive measure to cover the numerous polymorphisms dispersed in the ABO gene. A few studies have examined the diversity of the O allele compared to A or B subgroup alleles, resulting in antigenic changes. This study investigated the relationship between the serologic and molecular genetic characteristics of the O alleles in the Korean population. Methods: One hundred and five samples from healthy blood group O subjects were selected randomly. The isoagglutinin titer was measured using a tube agglutination and gel microcolumn assay. The ABO alleles were analyzed by sequencing exons 6 and 7 of the ABO gene. When the origin of a heterozygous nucleotide sequence was ambiguous, it was separated into a single allele using mono-allele amplification or cloning. Results: The median IgM isoagglutinin titer was eight. In contrast, the median IgG anti-A and anti-B isoagglutinin titers were 64 and 32, respectively. The IgG isoagglutinin titer showed a significant increase with age (P＜0.0001). Six O alleles were observed in 105 blood group O populations by sequencing. The O01 and O02 alleles were common (0.57, 0.36). Three rare O alleles (O04, O05, and O06) and one novel non-deletional O allele were found. Conclusion: The distribution of isoagglutinin titers of blood group O and the genetic frequency of O alleles in this study would form the basis of the development and interpretation of ABO genotyping and serologic workup in the Korean population. (Korean J Blood Transfus 2019;30:124-137)
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참고문헌 (30)
참고문헌 신청
Olsson ML / 2001 / Genomic analysis of clinical samples with serologic ABO blood grouping discrepancies:identification of 15 novel A and B subgroup alleles / Blood 98:1585~1593
Mazda T / 2007 / Differences in ABO antibody levels among blood donors: a comparison between past and present Japanese, Laotian, and Thai populations / Immunohematology 23:38~41
조치현 / 2011 / ABO 동종 응집소 역가 측정을 위한 시험관 및 미세원주응집법의 평가 / Laboratory Medicine Online 1(1):57~63
Kim JS / 1997 / Evaluation of ABO isoagglutinin titers in Korean adults / Korean J Blood Transfus 8:119~124
Yamamoto F / 1990 / Molecular genetic basis of the histo-blood group ABO system / Nature 345:229~233
Mazda T / 2007 / Differences in ABO antibody levels among blood donors: a comparison between past and present Japanese, Laotian, and Thai populations / Immunohematology 23:38~41
조치현 / 2011 / ABO 동종 응집소 역가 측정을 위한 시험관 및 미세원주응집법의 평가 / Laboratory Medicine Online 1(1):57~63
Kim JS / 1997 / Evaluation of ABO isoagglutinin titers in Korean adults / Korean J Blood Transfus 8:119~124
Yamamoto F / 1990 / Molecular genetic basis of the histo-blood group ABO system / Nature 345:229~233
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