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자료유형
학술저널
저자정보
저널정보
대한바이러스학회 JOURNAL OF BACTERIOLOGY AND VIROLOGY 大韓바이러스學會誌 제20권 제2호
발행연도
1990.12
수록면
159 - 165 (7page)

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초록· 키워드

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Nine clinically apparent infections with Hantaan and Seoul virus, the etiologic agents of hemorrhagic fever with rneal syndrome (HFRS), occurred in persons exposed to the virus at the Institute for Viral Diseases, Korea University, between 1971 and 1979. All were directly related to trapping of wild rodents or work with naturally or experimentally infected wild and laboratory rodents in a designated animal suite. All persons working in this environment, as well as two casual visitors, eventually become infected, whereas seven persons working with infected animal tissues and cell cultures in another building during this long interval exhibited neither clinical or subclinical manifestation of HFRS. All infections were acquired during the months of November to April, and none were associated with accidental parenteral inoculations, suggesting that aerosols produced by chronically infected rodents were the infectious vehicles and that lirnited air circulation and lowered humidity in the animal rooms during winter months increased the probability of virus transmission. Five infections were clinically mild febrile episodes of five days or less and did not require hospitalization. Four other patients were treated in a hospital for 2-8 weeks, peritoneal dialysis was required to manage acute renal failure in three of these individuals, Four persons, including two casual visitors, becarne ill within four months after initiation of experimental studies of Wistar rats with Hantaan and Seoul viruses, suggesting that this rodent may be a highly infectious host for Seoul virus.

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