지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Objectives : This study was aimed at examining the effects of the application of EA (electroacupuncture) at GV20 and LI4 in the early cerebral ischemia on the size of cerebral infarction, COX-2 and IL-6.
Methods : For this experiment, 21, six-week-old male S-D (Sprague - Dawley) rats weighting 160g to 200g were selected and randomly classified into 3 groups, seven rats in each group. Brain ischemia was simulated using a modified Koizumi method which was performed on each rat. In the GV20 group, the GV20 of the SD rats was stimulated for thirty minutes with acupunctural electrode low frequency stimulator five hours after inducement of ischemia. For the LI4 group, the LI4 was stimulated as above, while for the Ischemia group, no stimulation was applied. Twenty-four hours after the experiment, stained cerebral tissues were examined and an immuno-histological test was done to examine inflammatory reaction
Results : Out of the three groups, the LI4 group showed the smallest size of cerebral infarction and the Ischemia group showed the highest COX-2 (cyclooxygenase-2) expression value in the cortex of the cerebrum. In addition, the LI4 group showed the lowest COX-2 expression value in unknown putamen out of the three groups.
Conclusions : We infer that EA, applied at LI4 and GV20 in early ischemia, is effective in delaying the expression of IL-6 (interleukin-6) and COX-2, the inflammatory agents manifested from stroke. In addition, application at LI4, rather than GV20, can lower the expression value of the inflammatory agents. Further, EA can be an effective way to block early inflammatory reaction in stroke.
Methods : For this experiment, 21, six-week-old male S-D (Sprague - Dawley) rats weighting 160g to 200g were selected and randomly classified into 3 groups, seven rats in each group. Brain ischemia was simulated using a modified Koizumi method which was performed on each rat. In the GV20 group, the GV20 of the SD rats was stimulated for thirty minutes with acupunctural electrode low frequency stimulator five hours after inducement of ischemia. For the LI4 group, the LI4 was stimulated as above, while for the Ischemia group, no stimulation was applied. Twenty-four hours after the experiment, stained cerebral tissues were examined and an immuno-histological test was done to examine inflammatory reaction
Results : Out of the three groups, the LI4 group showed the smallest size of cerebral infarction and the Ischemia group showed the highest COX-2 (cyclooxygenase-2) expression value in the cortex of the cerebrum. In addition, the LI4 group showed the lowest COX-2 expression value in unknown putamen out of the three groups.
Conclusions : We infer that EA, applied at LI4 and GV20 in early ischemia, is effective in delaying the expression of IL-6 (interleukin-6) and COX-2, the inflammatory agents manifested from stroke. In addition, application at LI4, rather than GV20, can lower the expression value of the inflammatory agents. Further, EA can be an effective way to block early inflammatory reaction in stroke.
목차
Introduction
Material and Methods
Results
Discussion
Conclusion and Proposal
References
참고문헌 (37)
참고문헌 신청
1. [단행본] - Susan BO / 2007 / Physical Rehabilitation / Assessment and Treatment : 345 ~ 350
2. [단행본] - Randall LB / 2007 / Physical Therapy Medicine & Rehabilitation / Saunders Elsevier : 1175 ~ 1212
3. [학술지(정기간행물)] - Frank KH / 2002 / Does Acupuncture Improve Motor Recovery After Stroke? / Stroke 33 : 2604 ~ 2619
4. [학술지(정기간행물)] - Bannerman R / 1979 / Acupuncture: The World Health Organization view / World Health 32 : 24 ~ 29
5. [학술지(정기간행물)] - Newberg AB / 1998 / Determination of cerebral blood flow correlates of acupuncture using Tc-99m HMPAO SPECT imaging / Clin Nucl Med 23 : 791 ~
2. [단행본] - Randall LB / 2007 / Physical Therapy Medicine & Rehabilitation / Saunders Elsevier : 1175 ~ 1212
3. [학술지(정기간행물)] - Frank KH / 2002 / Does Acupuncture Improve Motor Recovery After Stroke? / Stroke 33 : 2604 ~ 2619
4. [학술지(정기간행물)] - Bannerman R / 1979 / Acupuncture: The World Health Organization view / World Health 32 : 24 ~ 29
5. [학술지(정기간행물)] - Newberg AB / 1998 / Determination of cerebral blood flow correlates of acupuncture using Tc-99m HMPAO SPECT imaging / Clin Nucl Med 23 : 791 ~
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UCI(KEPA) : I410-ECN-0101-2014-519-000263677