지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Objectives : Sesamin, a major lignan in sesame seeds, has been reported to have neuroprotective effects against in vitro ischemia and in vivo MCAo-reperfusion cerebral ischemia model, however, there is no reports in an in vivo global cerebral ischemia model. The purpose of the study was to investigate the neuroprotective effect of sesamin in global cerebral ischemia induced by four-vessel occlusion (4-VO) in rats through inhibition of microglial activation in this model. Methods : The neuroprotective effects were investigated using a 10 min of 4-VO ischemia rat model by measuring intact pyramidal neurons in the CA1 region of the hippocampus using Nissle staining. The antiinflammatory or reducing neurotoxicity effect was investigated using immunohistochemisty, RT-PCR and western blot analysis of inflammatory or neurotoxic mediators. Results : Intraperitoneal injection of sesamin at doses of 0.3, 1.0, 3.0, and 10.0 mg/kg at 0 min and 90 min after ischemia conferred 26.6%, 30.1%, 42.5%, and 30.5% neuroprotection, respectively, compared to the vehicle-treated control group. A 3.0 mg/kg dose of sesamin inhibited microglia activation and consequently, cyclooxygenase-2, inducible nitric oxide, and interleukine-$1{\beta}$ expressions at 48 h after reperfusion. Conclusions : Sesamin protects neuronal cell death through inhibition of microglial activation or the production of neurotoxic metabolites and proinflammatory mediators by microglia such as COX-2, iNOS and IL-$1{\beta}$ in global cerebral ischemia.
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참고문헌 (36)
참고문헌 신청
Park SH / 2010 / Antioxidants components as potential neuroprotective agents in sesame (Sesamum indicum L.) / Food Rev Int 26:103~121
Ryu SR / 1992 / Quantitative analysis of antioxidants in Sesame seed / Korean J Crop Sci 37:377~382
Cooney RV / 2001 / Effects of dietary sesame seeds on plasma tocopherol levels / Nutr Cancer 39:66~71
Khan MM / 2010 / Sesamin attenuates behavioral, biochemical and histological alterations induced by reversible middle cerebral artery occlusion in the rats / Chem Biol Interact 183:255~263
Ohnishi M / 2013 / Sesamin suppresses activation of microglia and p44/42 MAPK pathway, which confers neuroprotection in rat intracerebral hemorrhage / Neurosci 232:45~52
Ryu SR / 1992 / Quantitative analysis of antioxidants in Sesame seed / Korean J Crop Sci 37:377~382
Cooney RV / 2001 / Effects of dietary sesame seeds on plasma tocopherol levels / Nutr Cancer 39:66~71
Khan MM / 2010 / Sesamin attenuates behavioral, biochemical and histological alterations induced by reversible middle cerebral artery occlusion in the rats / Chem Biol Interact 183:255~263
Ohnishi M / 2013 / Sesamin suppresses activation of microglia and p44/42 MAPK pathway, which confers neuroprotection in rat intracerebral hemorrhage / Neurosci 232:45~52
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