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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.4
- 수록면
- 367 - 372 (6page)
이용수
초록· 키워드
오류제보하기
Cellular protection against carcinogens could be achieved by the induction of phase 2 detoxifying and antioxidant enzymes such as glutathione S-transferase (GST), NAD(P)H:quinone oxidoreductase 1 (NQO1) and heme oxygenase 1 (HO-1). Nuclear transcription factor E2-related factor 2 (Nrf2) binds to antioxidant response element (ARE) in the promoter region of these genes and the resulting transactivation occurs. In the present study the effect of gujeolcho (Chrysanthemum zawadskii) roots on the Nrf2-ARE pathway were investigated. C. zawadskii root extract was fractionated with a series of organic solvents and their ability to induce Nrf2-ARE pathway was examined. We separated the most potent dichloromethane (DCM) fraction into 12 sub-fractions and found several sub-fractions with strong effects on the Nrf2-ARE pathway. Fraction 4 strongly induced the ARE-reporter gene activity as well as Nrf2 expression. Sitosterol was isolated as a major compound in fraction 4 although its activity was not as potent as its mother fraction. These results indicate that C. zawadskii roots might be used as a potential natural chemopreventive source.
목차
Abstract
Introduction
Materials and Methods
Results and Discussion
Acknowledgment
References
참고문헌 (25)
참고문헌 신청
1. [학술지(정기간행물)] - Itoh K / 1997 / An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements / Biochem. Bioph. Res. Co 236 : 313 ~ 322
2. [학술지(정기간행물)] - Kong AN / 2001 / Signal transduction events elicited by cancer prevention compounds / Mutat. Res 480-481 : 231 ~ 241
3. [학술지(정기간행물)] - Jeong WS / 2006 / Nrf2: A potential molecular target for cancer chemoprevention by natural compounds / Antioxid. Redox. Sign 8 : 99 ~ 106
4. [학술지(정기간행물)] - Kim YY / 2001 / Biological activities of linarin from Chrysanthemum zawadskii var. latilobum / Yakhak Hoeji 45 : 604 ~ 610
5. [학술지(정기간행물)] - Lee JS / 2003 / A new anti-HIV flavonoid glucuronide from Chrysanthemum morifolium / Planta Med 69 : 859 ~ 861
2. [학술지(정기간행물)] - Kong AN / 2001 / Signal transduction events elicited by cancer prevention compounds / Mutat. Res 480-481 : 231 ~ 241
3. [학술지(정기간행물)] - Jeong WS / 2006 / Nrf2: A potential molecular target for cancer chemoprevention by natural compounds / Antioxid. Redox. Sign 8 : 99 ~ 106
4. [학술지(정기간행물)] - Kim YY / 2001 / Biological activities of linarin from Chrysanthemum zawadskii var. latilobum / Yakhak Hoeji 45 : 604 ~ 610
5. [학술지(정기간행물)] - Lee JS / 2003 / A new anti-HIV flavonoid glucuronide from Chrysanthemum morifolium / Planta Med 69 : 859 ~ 861
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UCI(KEPA) : I410-ECN-0101-2013-573-001015502