지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Journal of Food Science and Nutrition Journal of Food Science and Nutrition Vol.10 No.4
- 발행연도
- 2005.12
- 수록면
- 340 - 343 (4page)
이용수
초록· 키워드
오류제보하기
Induction of NAD(P)H:(quinone-acceptor) oxidoreductase (QR) which promotes obligatory two electron reduction of quinones and prevents their participation in oxidative cycling and thereby the depletion of intracellular glutathione, has been used as a marker for chemopreventive agents. Induction of phase II enzyme is considered to be an important mechanism of cancer prevention. In our previous study, we assessed the quinone reductase QR-inducing activities of 216 kinds of medicinal herb extracts in cultured murine hepatoma cells, BPRc1 and hepa1c1c7 cells. Among the 216 herbal extracts tested in that study, extracts from Chrysanthemum zawadskii showed significant induction of QR. In this study, we examined QR-inducing activity of solvent fractions of the herbal extract. The dichloromethane fraction of the herb showed the highest QR induction among the samples fractionated with four kinds of solvents with different polarity. The fraction also significantly induced the activity of glutathione S-transferase (GST), one of the major detoxifying enzymes, at 4 μg/mL and 2 μg/mL in hepa1c1c7 and BPRc1 cells, respectively. In conclusion, dichloromethane-soluble fraction of Chrysanthemum zawadskii which showed relatively strong induction of detoxifying enzymes merits further study to identify active components and evaluate their potential as cancer preventive agents.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
참고문헌 (11)
참고문헌 신청
Prestera T, Holtzclaw WD, Zhang YS, Talalay P. 1993. Chemical and molecular regulation of enzymes that detoxify carcinogens. Proc Natl Acad Sci USA 90: 2965-2969.
De Long MJ, Prochaska HJ, Talalay P. 1986. Induction of NAD(P)H:quinone reductase in murine hepatoma cells by phenolic antioxidants, azo dyes, and other chemoprotectors: A model system for the study of anticarcinogens. Proc Natl Acad Sci USA 83: 787-791.
Iida K, Itoh K, Kumagai Y, Oyasu R, Hattori K, Kawai K, Shimazui T, Akaza H, Yamamoto M. 2004. Nrf2 is essential for the chemopreventive efficacy of oltipraz against urinary bladder carcinogenesis. Cancer Res 64: 6424-6431.
Ross D, Kepa JK, Winski SL, Beall HD, Anwar A, Siegel D. 2000. NAD(P)H:quinone oxidoreductase 1 (NQO1): chemoprotection, bioactivation, gene regulation and genetic polymorphisms. Chem Biol Interact 129: 77-97.
Ebert B, Seidel A, Lampen A. 2005. Induction of phase-1 metabolizing enzymes by oltipraz, flavone and indole-3- carbinol enhance the formation and transport of benzo[a]- pyrene sulfate conjugates in intestinal Caco-2 cells. Toxicol Lett 158: 140-151.
De Long MJ, Prochaska HJ, Talalay P. 1986. Induction of NAD(P)H:quinone reductase in murine hepatoma cells by phenolic antioxidants, azo dyes, and other chemoprotectors: A model system for the study of anticarcinogens. Proc Natl Acad Sci USA 83: 787-791.
Iida K, Itoh K, Kumagai Y, Oyasu R, Hattori K, Kawai K, Shimazui T, Akaza H, Yamamoto M. 2004. Nrf2 is essential for the chemopreventive efficacy of oltipraz against urinary bladder carcinogenesis. Cancer Res 64: 6424-6431.
Ross D, Kepa JK, Winski SL, Beall HD, Anwar A, Siegel D. 2000. NAD(P)H:quinone oxidoreductase 1 (NQO1): chemoprotection, bioactivation, gene regulation and genetic polymorphisms. Chem Biol Interact 129: 77-97.
Ebert B, Seidel A, Lampen A. 2005. Induction of phase-1 metabolizing enzymes by oltipraz, flavone and indole-3- carbinol enhance the formation and transport of benzo[a]- pyrene sulfate conjugates in intestinal Caco-2 cells. Toxicol Lett 158: 140-151.
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UCI(KEPA) : I410-ECN-0101-2009-511-015199830