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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.10
- 수록면
- 728 - 733 (6page)
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초록· 키워드
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Bamboo grass, Sasa quelpaertensis, is a native plant to Jeju Island, Korea. The leaves of Sasa plants are widely used in traditional Korean medicine to treat inflammation-related diseases. We investigated the effect of hot water extract from Sasa quelpaertensis leaves (HWE-SQ) on nitric oxide (NO) production and nuclear factor-κB (NF-κB) activation in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. HWE-SQ inhibited LPS-induced NO production and inducible NO synthase (iNOS) protein expression in a dose-dependent manner. Reporter gene assays indicated that HWE-SQ decreases LPS-induced NF-κB transcriptional activation. However, HWE-SQ did not affect the phosphorylation and degradation of inhibitory κBα (IκBα). HWE-SQ also directly inhibited iNOS enzyme activity in a dose-dependent manner. These results suggest that HWE-SQ suppresses NO synthesis in macrophages by attenuating NF-κB-mediated iNOS protein expression and inhibiting iNOS enzymatic activity, thereby implicating a mechanism by which HWE-SQ is able to ameliorate inflammationrelated diseases by limiting excessive or prolonged NO production in pathological events.
목차
Abstract
Introduction
Materials and Methods
Results and Discussion
Acknowledgments
References
참고문헌 (42)
참고문헌 신청
1. [학술지(정기간행물)] - Hobbs AJ / 1999 / Inhibition of nitric oxide synthase as a potential therapeutic target 39 : 191 ~ 220
2. [학술지(정기간행물)] - Alderton WK / 2001 / Nitric oxide synthases: structure, function, and inhibition 357 : 593 ~ 615
3. [학술지(정기간행물)] - Wang Y / 1995 / Nitric oxide synthases: gene structure and regulation 34 : 71 ~ 90
4. [학술지(정기간행물)] - Bogdan C / 2001 / Nitric oxide and the immune response 2 : 907 ~ 916
5. [학술지(정기간행물)] - Luoma JS / 1998 / Expression of extracellular SOD and iNOS in macrophages and smooth muscle cells in human and rabbit atherosclerotic lesions: colocalization with epitopes characteristic of oxidized LDL and peroxynitrite-modified proteins 18 : 157 ~ 167
2. [학술지(정기간행물)] - Alderton WK / 2001 / Nitric oxide synthases: structure, function, and inhibition 357 : 593 ~ 615
3. [학술지(정기간행물)] - Wang Y / 1995 / Nitric oxide synthases: gene structure and regulation 34 : 71 ~ 90
4. [학술지(정기간행물)] - Bogdan C / 2001 / Nitric oxide and the immune response 2 : 907 ~ 916
5. [학술지(정기간행물)] - Luoma JS / 1998 / Expression of extracellular SOD and iNOS in macrophages and smooth muscle cells in human and rabbit atherosclerotic lesions: colocalization with epitopes characteristic of oxidized LDL and peroxynitrite-modified proteins 18 : 157 ~ 167
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UCI(KEPA) : I410-ECN-0101-2013-573-001011140