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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.10
- 수록면
- 1,063 - 1,070 (8page)
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Dangyuja (Citrus grandis Osbeck) is a native plant growing only on Jeju Island in Korea. In this study, antiinflammatory effect of dangyuja leaves on a murine macrophage cell line was investigated. RAW 264.7 murine macrophage cells were stimulated with lipopolysaccharide (LPS, 1 ㎍/㎖) to induce expression of pro-inflammatory markers [interleukin (IL)-6 and inducible nitric oxide synthase (iNOS)]. The crude extract (80% MeOH Ex.) and solvent fractions (hexane, CHCl3, EtOAc, BuOH, and H₂O Ex.) were obtained from dangyuja leaves. The CHCl3 fraction inhibited the nitric oxide (NO) and IL-6 production in a dose-dependent manner. Also, the CHCl₃ fraction inhibited mRNA expression and protein levels of iNOS in a dose-dependent manner. Furthermore, the CHCl₃ fraction inhibited LPS-induced nuclear factor (NF)-κB activation and phosphorylation of mitogen-activated protein kinases (MAPKs: ERK, JNK, and p38). These results suggest that dangyuja leaves may inhibit LPS-induced production of inflammatory markers by blocking NF-κB and MAPKs signaling in RAW 264.7 cells.
목차
Abstract
Introduction
Materials and Methods
Results and Discussion
Acknowledgments
References
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당유자청의 제조방법과 냉동 저장기간이 당유자차 기호도에 미치는 영향
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In vitro Antioxidant and Cytoprotective Activities of the Extract of Dangyuja (Citrus grandis Osbeck) Leaves
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Antioxidant Activity of Extracts from Dangyuja (Cirus grandis Osbeck) Fruits Produced in Jeju Island
Food Science and Biotechnology
2006 .04
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Induction of Apoptosis in SNU-16 Human Gastric Cancer Cells by the Chloroform Fraction of an Extract of Dangyuja (Citrus grandis) Leaves
Applied Biological Chemistry
2009 .01
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Cedrela sinensis Leaves Suppress Oxidative Stress and Expressions of iNOS and COX-2 via MAPK Signaling Pathways in RAW 264.7 Cells
Journal of Food Science and Nutrition
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Ethanolic Extract of Chondria crassicaulis Inhibits the Expression of Inducible Nitric Oxide Synthase and Cyclooxygenase-2 in LPS-Stimulated RAW 264.7 Macrophages
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Codium fragile Ethanol Extraction Inhibited Inflammatory Response through the Inhibition of JNK Phosphorylation
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Induction of apoptosis and cell cycle arrest in HCT-116 cells by polymethoxy flavon rich fractions from Citru grandis Osbeck (Dangyuja) peel extracts
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UCI(KEPA) : I410-ECN-0101-2013-573-000874178