지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Journal of Food Science and Nutrition Journal of Food Science and Nutrition Vol.15 No.1
- 발행연도
- 2010.3
- 수록면
- 14 - 18 (5page)
이용수
초록· 키워드
오류제보하기
Stevia rebaudiana (SR) is an herb used traditionally as a sweetener in Paraguay and Brazil, whose use is spreading to other countries, such as Japan, Korea and China. In addition to its low calorie sweet taste, SR appears to have other beneficial properties, such as hypotensive capabilities and inflammation reduction. To identify the bioactive natural constituents exerting anti-inflammatory activities, we examined the EtOAc fraction of SR. In the inflammatory mediator inhibitory assay from lipopolysaccharide (LPS)-activated macrophages, the EtOAc fraction significantly, and dose dependently, inhibited the enhanced production of nitric oxide (NO) and inducible nitric oxide synthase (iNOS) expression. We also found that treatment of cells with the EtOAc fraction significantly inhibited LPS-stimulated nuclear factor-κB (NF-κB) reporter gene expression. Such inhibition of NF-κB was closely associated with the inhibition of interleukin-6 (IL-6) and the monocyte chemoattractant protein-1 (MCP-1). Therefore, we suggest that SR has the potential for development as a functional food for the treatment of immune diseases, such as rheumatoid arthritis and lupus.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
ACKNOWLEDGMENTS
REFERENCES
참고문헌 (16)
참고문헌 신청
1. [학술지(정기간행물)] - Nathan C. / 1992 / Nitric oxide: discovery and impact on clinical medicine / FASEB J. 92 : 164 ~ 169
2. [학술지(정기간행물)] - Szekancecz Z. / 2007 / Macrophages and their products in rheumatoid arthritis / Curr. Opin. Rheumatol. 19 : 289 ~ 295
3. [학술지(정기간행물)] - Mörmann M. / 2008 / Lipopolysaccharides (LPS) induce the differentiation of human monocytes to osteoclasts in a tumour necrosis factor (TNF) alpha-dependent manner: a link between infection and pathological bone resorption / Mol. Immunol. 45 : 3330 ~ 3337
4. [학술지(정기간행물)] - Baeuerle A. / 1994 / Function and activation of NF-κB in the immune system.Annu Rev Immunol 12:141-179 / Annu. Rev. Immunol. 12 : 141 ~ 179
5. [학술지(정기간행물)] - Baldwin R. / 1996 / The NF-κB and IκB Proteins: new discoveries and insights / Annu. Rev. Immunol. 14 : 649 ~ 683
2. [학술지(정기간행물)] - Szekancecz Z. / 2007 / Macrophages and their products in rheumatoid arthritis / Curr. Opin. Rheumatol. 19 : 289 ~ 295
3. [학술지(정기간행물)] - Mörmann M. / 2008 / Lipopolysaccharides (LPS) induce the differentiation of human monocytes to osteoclasts in a tumour necrosis factor (TNF) alpha-dependent manner: a link between infection and pathological bone resorption / Mol. Immunol. 45 : 3330 ~ 3337
4. [학술지(정기간행물)] - Baeuerle A. / 1994 / Function and activation of NF-κB in the immune system.Annu Rev Immunol 12:141-179 / Annu. Rev. Immunol. 12 : 141 ~ 179
5. [학술지(정기간행물)] - Baldwin R. / 1996 / The NF-κB and IκB Proteins: new discoveries and insights / Annu. Rev. Immunol. 14 : 649 ~ 683
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UCI(KEPA) : I410-ECN-0101-2010-511-002141858