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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 275 - 282 (8page)
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초록· 키워드
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Inflammatory mediators such as inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) have been implicated in various inflammatory diseases. In this study, we investigated the anti-inflammatory activities of Chondria crassicaulis ethanolic extract (CCE) by measuring its effects on the expression of iNOS and COX-2 proteins in lipopolysaccharide (LPS)-treated RAW 264.7 murine macrophages. CCE significantly and dose-dependently inhibited the LPS-induced release of nitric oxide and prostaglandin E_2, and suppressed the expression of iNOS and COX-2 proteins in LPS-stimulated RAW 264.7 cells, without causing any cytotoxicity. It also inhibited the production of the pro-inflammatory cytokines such as interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α in LPS-stimulated RAW 264.7 cells. Moreover, treatment with CCE strongly suppressed nuclear factor-κB (NF-κB) promoter-driven expression in LPS-treated RAW 264.7 cells. CCE treatment blocked nuclear translocation of the p65 subunit of NF-κB by preventing proteolytic degradation of inhibitor of κB-α. These results indicate that CCE regulates iNOS and COX-2 expression through NF-κB-dependent transcriptional control, and identifies potential candidates for the treatment or prevention of inflammatory diseases.
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참고문헌 (36)
참고문헌 신청
Nathan C / 1992 / Nitric oxide as a secretory product of mammalian cells / FASEB J 6:3051~3064
Packard RR / 2008 / Inflammation in atherosclerosis:from vascular biology to biomarker discovery and risk prediction / Clin Chem 54:24~38
Pan MH / 2011 / Se-methylselenocysteine inhibits lipopolysaccharide-induced NF-κB activation and iNOS induction in RAW 264.7 murine macrophages / Mol Nutr Food Res 55:723~732
Pinelo M / 2004 / Extraction of antioxidant phenolics from almond hulls(Prunus amygdalus)and pine sawdust(Pinus pinaster) / Food Chem 85:267~273
Rahman I / 2006 / Regulation of inflammation and redox signaling by dietary polyphenols / Biochem Pharmacol 72:1439~1452
Packard RR / 2008 / Inflammation in atherosclerosis:from vascular biology to biomarker discovery and risk prediction / Clin Chem 54:24~38
Pan MH / 2011 / Se-methylselenocysteine inhibits lipopolysaccharide-induced NF-κB activation and iNOS induction in RAW 264.7 murine macrophages / Mol Nutr Food Res 55:723~732
Pinelo M / 2004 / Extraction of antioxidant phenolics from almond hulls(Prunus amygdalus)and pine sawdust(Pinus pinaster) / Food Chem 85:267~273
Rahman I / 2006 / Regulation of inflammation and redox signaling by dietary polyphenols / Biochem Pharmacol 72:1439~1452
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