지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.12
- 수록면
- 299 - 305 (7page)
이용수
초록· 키워드
오류제보하기
KCNE1 is the causal gene of long QT syndrome. KCNE1 gene is located in chromosome 21. In compliance with this KCNE1 gene the proteins come out. KCNE1 is responsible for K? channel which maintains the normal function of the heart muscle for contraction. Affected individuals manifest prolongation of the QT interval on electrocardiongrams, a sign of abnormal cardiac repolarization. The clinical features of LQT result from episodic cardiac arrhythmias, such as torsade de pointes and ventricular fibrllation. Blood DNA was isolated and kept in 4℃ refrigerator. The KCNE1 gene was amplified by PCR method and about 414 bp band was identified by agarose gel electrophoresis. PCR products were inserted into pGEX-4T-1 vector in order to express KCNE1 protein after treatment with IPTG SDS-PAGE was carried out and the protein band which was about 47 kDa was clearly odserved. Results of this study would contribute to the detailed understanding of KCNE1 protein function and to designing better treatment of Long QT symdrome.
목차
서론
재료 및 방법
결과
고찰
Acknowlegment
REFERENCES
참고문헌 (20)
참고문헌 신청
1. [학술지(정기간행물)] - Ai T / 2002 / Novel KCNJ2 mutation in familial periodic paralysis with ventricular dysrhythmia / Circulation 105 : 2592 ~ 2594
2. [학술지(정기간행물)] - Curran ME / 1995 / A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome / Cell 80 : 795 ~ 803
3. [학술지(정기간행물)] - Geelen JL / 1998 / Molecular genetics of inherited long QT syndromes / Eur Heart J. 19 : 1427 ~ 1423
4. [학술지(정기간행물)] - Hirao H / 1996 / Frequency-dependent electophysiologic properties of ventricular repolarization in patients with congenital long QT syndrome / J Am Coll Cardiol 28 : 1269 ~ 1277
5. [학술지(정기간행물)] - Jervell A / 1957 / Coneenital deaf-mutism, functional heart disease with prolongation of the QT interval, and sudden death / Am Heart J. 54 : 59 ~ 68
2. [학술지(정기간행물)] - Curran ME / 1995 / A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome / Cell 80 : 795 ~ 803
3. [학술지(정기간행물)] - Geelen JL / 1998 / Molecular genetics of inherited long QT syndromes / Eur Heart J. 19 : 1427 ~ 1423
4. [학술지(정기간행물)] - Hirao H / 1996 / Frequency-dependent electophysiologic properties of ventricular repolarization in patients with congenital long QT syndrome / J Am Coll Cardiol 28 : 1269 ~ 1277
5. [학술지(정기간행물)] - Jervell A / 1957 / Coneenital deaf-mutism, functional heart disease with prolongation of the QT interval, and sudden death / Am Heart J. 54 : 59 ~ 68
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UCI(KEPA) : I410-ECN-0101-2012-510-004137291