지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.12
- 수록면
- 238 - 245 (8page)
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Objectives：Abnormalities in the QT interval have been associated with an increased risk of ventricular arrhythmias and sudden cardiac death. However, there is no clear correlation between cigarette smoking and QT interval prolongation in schizophrenia. The purpose of this study is to evaluate the effects of cigarette smoking on the QT interval and estimate the prevalence of prolonged QT interval in schizophrenic patients who take antipsychotics.
Methods：We studied 106 schizophrenic patients taking antipsychotics and age- and sex-matched 106 people in control group. A prolonged QTc interval was defined as ＞450 msec in men and ＞470 msec in women. The demographic data and clinical characteristics of subjects were collected from medical records. The correlations between QTc interval and other variables were assessed using a regression analysis.
Results：There was no significant association between cigarette smoking and QT interval. The mean QT interval was not significantly influenced by antipsychotic dose and type of antipsychotics. However, there was significantly prolonged QT interval in schizophrenic patients(421.1±25.7 msec) compared to control group(412.1±17.1 msec) (p=0.003). The prevalence of prolonged QT interval in schizophrenic patients was 6.6%(7 of 106 patients). Five patients( 71.4%) were smoker and six patients(85.7%) had obesity. By contrast, nobody had a prolonged QT interval in control group.
Conclusions：The prevalence of prolonged QT interval was relatively high among middle aged schizophrenia patients. And there was significantly prolonged QT interval and higher body mass index in schizophrenia patients.
Methods：We studied 106 schizophrenic patients taking antipsychotics and age- and sex-matched 106 people in control group. A prolonged QTc interval was defined as ＞450 msec in men and ＞470 msec in women. The demographic data and clinical characteristics of subjects were collected from medical records. The correlations between QTc interval and other variables were assessed using a regression analysis.
Results：There was no significant association between cigarette smoking and QT interval. The mean QT interval was not significantly influenced by antipsychotic dose and type of antipsychotics. However, there was significantly prolonged QT interval in schizophrenic patients(421.1±25.7 msec) compared to control group(412.1±17.1 msec) (p=0.003). The prevalence of prolonged QT interval in schizophrenic patients was 6.6%(7 of 106 patients). Five patients( 71.4%) were smoker and six patients(85.7%) had obesity. By contrast, nobody had a prolonged QT interval in control group.
Conclusions：The prevalence of prolonged QT interval was relatively high among middle aged schizophrenia patients. And there was significantly prolonged QT interval and higher body mass index in schizophrenia patients.
목차
서론
대상 및 방법
결과
고찰
참고문헌
참고문헌 (43)
참고문헌 신청
1. [학술지(정기간행물)] - Osby U / 2000 / Mortality and causes of death in schizophrenia in Stockholm county, Sweden / Schizophr Res 45 : 21 ~ 28
2. [학술지(정기간행물)] - Saha S / 2007 / A systematic review of mortality in schizophrenia: is the differential mortality gap worsening over time? / Arch Gen Psychiatry 64 : 1123 ~ 1131
3. [학술지(정기간행물)] - Laursen TM / 2012 / Life expectancy and cardiovascular mortality in persons with schizophrenia / Curr Opin Psychiatry 25 : 83 ~ 88
4. [학술지(정기간행물)] - Wildgust HJ / 2010 / The paradox of premature mortality in schizophrenia: new research questions / J Psychopharmacol 24 : 9 ~ 15
5. [학술지(정기간행물)] - Wildgust HJ / 2010 / Are there modifiable risk factors which will reduce the excess mortality in schizophrenia? / J Psychopharmacol 24 : 37 ~ 50
2. [학술지(정기간행물)] - Saha S / 2007 / A systematic review of mortality in schizophrenia: is the differential mortality gap worsening over time? / Arch Gen Psychiatry 64 : 1123 ~ 1131
3. [학술지(정기간행물)] - Laursen TM / 2012 / Life expectancy and cardiovascular mortality in persons with schizophrenia / Curr Opin Psychiatry 25 : 83 ~ 88
4. [학술지(정기간행물)] - Wildgust HJ / 2010 / The paradox of premature mortality in schizophrenia: new research questions / J Psychopharmacol 24 : 9 ~ 15
5. [학술지(정기간행물)] - Wildgust HJ / 2010 / Are there modifiable risk factors which will reduce the excess mortality in schizophrenia? / J Psychopharmacol 24 : 37 ~ 50
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UCI(KEPA) : I410-ECN-0101-2014-513-000468594