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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국원예학회 HORTICULTURE ENVIRONMENT and BIOTECHNOLOGY HORTICULTURE ENVIRONMENT and BIOTECHNOLOGY Vol.51 No.6
- 발행연도
- 2010.12
- 수록면
- 539 - 544 (6page)
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초록· 키워드
오류제보하기
The antioxidant and antiproliferation effects of fractions from methanol extract of Sparganiun stoloniferum were investigated in this study. The ethyl acetate fraction of the methanol extract showed significant antioxidant activity against α,α-diphenyl-picrylhydrazyl (DPPH) and hydroxyl (ㆍOH) radical scavenging, and it showed greater reducing power than the n-hexane, dichloromethane, n-butanol and water fractions. Qualitative HPLC analysis was performed on the extractions. The high content of phenolics in ethyl acetate fractions were believed to be responsible for its antioxidant activity, which was the strongest in all five fractions. Moreover, the ethyl acetate fraction showed a dose-dependent inhibition of cell proliferation with an EC?? of 139.21 ± 0.54 μgㆍmL?¹ against the human colon cell, HT-29. The anti-proliferative effects of the ethyl acetate fraction were associated with apoptosis. Semi-quantitative RT-PCR analysis indicates that, after treatment with the ethyl acetate fraction, the expression of caspase-3, p53, and Bax in HT-29 cells was significantly up-regulated and c-myc expression was induced. These findings demonstrate that the ethyl acetate fraction of S. stoloniferum has potent antioxidant and antiproliferation effects and induces apoptosis. Thus, the extract of S. stoloniferum may be considered as a potential functional food resource and complementary medicinal supplement.
목차
Abstract
Introduction
Materials and Methods
Results and Discussion
Conclusion
Literature Cited
참고문헌 (29)
참고문헌 신청
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2. [학술지(정기간행물)] - Benzie, I.F. / 2000 / Evolution of antioxidant defense mechanisms / European J. Nutr 39 : 53 ~ 61
3. [학술지(정기간행물)] - Chiu, S.M. / 2003 / Bax is essential for mitochondrion-mediated apoptosis but not for cell death caused by photodynamic therapy / Brit. J. Cancer 89 : 1590 ~ 1597
4. [학술지(정기간행물)] - Chou, S.T. / 2003 / Antioxidative activity and safety of 50% ethanolic red bean extract (Phaseolus radiatus L. var. Aurea) / J. Food Sci 68 : 21 ~ 25
5. [학술지(정기간행물)] - Dorman, H.J. / 2003 / Characterisation of the antioxidant properties of de-odourised aqueous extracts from selected Lamiaceae herbs / Food Chem 83 : 255 ~ 262
2. [학술지(정기간행물)] - Benzie, I.F. / 2000 / Evolution of antioxidant defense mechanisms / European J. Nutr 39 : 53 ~ 61
3. [학술지(정기간행물)] - Chiu, S.M. / 2003 / Bax is essential for mitochondrion-mediated apoptosis but not for cell death caused by photodynamic therapy / Brit. J. Cancer 89 : 1590 ~ 1597
4. [학술지(정기간행물)] - Chou, S.T. / 2003 / Antioxidative activity and safety of 50% ethanolic red bean extract (Phaseolus radiatus L. var. Aurea) / J. Food Sci 68 : 21 ~ 25
5. [학술지(정기간행물)] - Dorman, H.J. / 2003 / Characterisation of the antioxidant properties of de-odourised aqueous extracts from selected Lamiaceae herbs / Food Chem 83 : 255 ~ 262
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UCI(KEPA) : I410-ECN-0101-2012-525-003764471