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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Journal of Food Science and Nutrition Journal of Food Science and Nutrition Vol.15 No.4
- 발행연도
- 2010.12
- 수록면
- 267 - 274 (8page)
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초록· 키워드
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We assessed the effect of Se-methylselenocysteine (MSC) treatment, at a dose of 0.75 mg/rat/day for 1 or 2 weeks, on the activities of antioxidant systems in Sprague-Dawley rat tissues. Significant changes in glutathione and antioxidant enzyme activities, with different patterns among tissues, were evidenced. Glutathione content and its reduction state in the liver, lung, and kidney were elevated upon MSC treatment, whereas they were significantly lowered in the spleen. Among the tissues exhibiting glutathione increase, there were different enzymatic responses: g-glutamylcysteine ligase activity, the rate-limiting enzyme in the glutathione synthesis pathway, was increased in the liver, whereas the activities of the enzymes associated with glutathione recycling, namely, glutathione peroxidase, glutathione reductase, and glucose 6-phosphate dehydrogenase, were significantly increased in the lung and the kidney. The superoxide dismutase activity was decreased in all tissues upon MSC treatment, whereas catalase activity was increased in all tissues but the liver. Lipid peroxidation level was transiently increased at 1 week in the lung and the kidney, whereas it was persistently increased in the spleen. The increase was not evident in the liver. The results indicate that the MSC treatment results in an increase in the antioxidant capacity of the liver, lung, and kidney principally via an increase in glutathione content and reduction, which appeared to be a result of increased synthesis or recycling of glutathione via tissue-dependent adaptive response to oxidative stress triggered by MSC. The spleen appeared to be very sensitive to oxidative stress, and therefore, the adaptive response could not provide protection against oxidative damage.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
참고문헌 (37)
참고문헌 신청
1. [학술지(정기간행물)] - Alissa EM / 2003 / The controversy surrounding selenium and cardiovascular disease: a review of the evidence / Med Sci Monit (9) : RA9 ~ 18
2. [학술지(정기간행물)] - Ellis DR / 2003 / Plants, selenium and human health / Curr Opin Plant Biol (6) : 273 ~ 279
3. [학술지(정기간행물)] - Pagmantidis V / 2008 / Supplementation of healthy volunteers with nutritionally relevant amounts of selenium increases the expression of lymphocyte protein biosynthesis genes / Am J Clin Nutr (87) : 181 ~ 189
4. [학술지(정기간행물)] - Clark LC / 1996 / Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial / JAMA (276) : 1957 ~ 1963
5. [학술지(정기간행물)] - Combs GF Jr / 1998 / Chemopreventive agents: selenium / Pharmacol Ther (79) : 179 ~ 192
2. [학술지(정기간행물)] - Ellis DR / 2003 / Plants, selenium and human health / Curr Opin Plant Biol (6) : 273 ~ 279
3. [학술지(정기간행물)] - Pagmantidis V / 2008 / Supplementation of healthy volunteers with nutritionally relevant amounts of selenium increases the expression of lymphocyte protein biosynthesis genes / Am J Clin Nutr (87) : 181 ~ 189
4. [학술지(정기간행물)] - Clark LC / 1996 / Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial / JAMA (276) : 1957 ~ 1963
5. [학술지(정기간행물)] - Combs GF Jr / 1998 / Chemopreventive agents: selenium / Pharmacol Ther (79) : 179 ~ 192
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UCI(KEPA) : I410-ECN-0101-2012-511-003794800