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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Journal of Food Science and Nutrition Journal of Food Science and Nutrition Vol.13 No.4
- 발행연도
- 2008.12
- 수록면
- 259 - 265 (7page)
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이 논문의 연구 히스토리 (2)
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초록· 키워드
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This study was designed to investigate the protective effect of fucoidan against AAPH-induced oxidative stress in LLC-PK1 cells (porcine kidney epithelial cells). Oxidative stress was induced by exposing of LLC-PK1 cells to the 1 mM 2,2'-azobis(2-amidino propane) dihydrochloride (AAPH) for 24 hr. Exposure of LLC-PK1 cells to 1 mM AAPH for 24 hr resulted in a significant (p＜0.05) decrease in cell viability, but fucoidan treatment protected LLC-PK1 cells from AAPH-induced cell damage in a dose dependant manner. To investigate the protective action of fucoidan against AAPH-induced damage of LLC-PK1 cells, we measured the effects of fucoidan on lipid peroxidation and antioxidant enzymes activities of AAPH treated cells as well as scavenging activities on superoxide anion radical and hydroxyl radical. Fucoidan had protective effect against the AAPH-induced LLC-PK1 cellular damage and decreased lipid peroxidation and increased activities of antioxidant enzymes such as superoxide dismutase (SOD) and glutathione peroxidase (GSH-px). Furthermore, fucoidan showed strong scavenging activity against superoxide anion radical. The IC?? value of fucoidan was 48.37±1.54 ㎍/mL for superoxide anion radical scavenging activity. The fucoidan also had high hydroxyl radical scavenging activity (IC??=32.03 ㎍/mL). These results indicate that fucoidan protects against AAPH-induced LLC-PK1 cell damage by inhibiting lipid peroxidation, increasing antioxidant enzyme activities and scavenging offree radicals.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
ACKNOWLEDGEMENT
REFERENCES
참고문헌 (41)
참고문헌 신청
1. [학술지(정기간행물)] - Miki M / 1987 / Free-radical chain oxidation of rat red blood cells by molecular oxygen and its inhibition by tocopherol / Arch Biochem Biophys 258 : 373 ~ 380
2. [학술지(정기간행물)] - Yokozawa T / 2000 / Antioxidative activity of green tea treated with radical initiator 2,2'-azobis(2-aminopropane) dihydrochloride / J Agric Food Chem 48 : 5068 ~ 5073
3. [학술지(정기간행물)] - Willcox JK / 2004 / Crit Rev Food Sci Nutr 44 : 275 ~ 295
4. [학술지(정기간행물)] - Kawanishi S / 2005 / The role of metals in site-specific DNA damage with reference to carcinogenesis / Free Radic Biol Med 32 : 822 ~ 832
5. [학술지(정기간행물)] - Sachidanandame K / 2005 / Oxidative stress and cardiovascular disease: antioxidants and unresolved issues / Cardiovasc Drug Rev 23 : 115 ~ 132
2. [학술지(정기간행물)] - Yokozawa T / 2000 / Antioxidative activity of green tea treated with radical initiator 2,2'-azobis(2-aminopropane) dihydrochloride / J Agric Food Chem 48 : 5068 ~ 5073
3. [학술지(정기간행물)] - Willcox JK / 2004 / Crit Rev Food Sci Nutr 44 : 275 ~ 295
4. [학술지(정기간행물)] - Kawanishi S / 2005 / The role of metals in site-specific DNA damage with reference to carcinogenesis / Free Radic Biol Med 32 : 822 ~ 832
5. [학술지(정기간행물)] - Sachidanandame K / 2005 / Oxidative stress and cardiovascular disease: antioxidants and unresolved issues / Cardiovasc Drug Rev 23 : 115 ~ 132
함께 읽어보면 좋을 논문
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