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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Journal of Food Science and Nutrition Journal of Food Science and Nutrition Vol.12 No.2
- 발행연도
- 2007.6
- 수록면
- 74 - 78 (5page)
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초록· 키워드
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Fucoidan, that is high-molecular-weight sulfated polysaccharides extracted from brown seaweeds has been shown to elicit various biological activities. Here, we investigated the effects of fucoidan on cell proliferation and nitric oxide (NO) production in neuronal blastoma cell (SH-SY5Y). In the present study, we demonstrated that fucoidan treatment resulted in increase of cell proliferation and NO production. When cells were treated with amyloid-β (Aβ) in the absence or presence of fucoidan, fucoidan recovered the cell viability decreased by Aβ peptides. To further determine whether nitric oxide synthase (NOS) is involved in proliferative effect of fucoidan, cells were treated with NOS inhibitors in the absence or presence of fucoidan. Selective constitutive nitric oxide synthase (cNOS) inhibitor, diphenylene iodonium chloride (DPI), caused a decrease of cell viability, whereas cell viability was increased by specific inducible nitric oxide synthase (iNOS) inhibitor, S-methylisothiourea (SMT), in the fucoidan-untreated cells. Treatment with fucoidan inhibited the cell viability decreased in DPI-exposed cells. In contrast, fucoidan had no effect on cell growth in SMT-treated cells, indicating that cNOS may not play a role in the proliferation of fucoidan-treated cells. The present data suggest that fucoidan has proliferative and neuroprotective effects and these effects may be associated with iNOS.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSIONS
ACKNOWLEDGEMENTS
REFERENCES
참고문헌 (25)
참고문헌 신청
Davis TA, Volesky B, Mucci A. 2003. A review of the biochemistry of heavy metal biosorption by brown algae. Water Res 37: 4311-4330.
Patel MK, Mulloy B, Gallagher KL, O'Brien L, Hughes AD. 2002. The antimitogenic action of the sulphated polysaccharide fucoidan differs from heparin in human vascular smooth muscle cells. Thromb Haemost 87: 149-154.
O'Leary R, Rerek M, Wood EJ. 2004. Fucoidan modulates the effect of transforming growth factor (TGF)-beta1 on fibroblast proliferation and wound repopulation in vitro models of dermal wound repair. Biol Pharm Bull 27: 266-270.
Mahony MC, Oehninger S, Clark GF, Acosta AA, Hodgen GD. 1991. Fucoidin inhibits the zona pellucida-induced acrosome reaction in human spermatozoa. Contraception 44: 657-665.
Baba M, Snoeck R, Pauwels R, de Clercq E. 1988. Sulfated polysaccharides are potent and selective inhibitors of various enveloped viruses, including herpes simplex virus, cytomegalovirus, vesicular stomatitis virus, and human immunodeficiency virus. Antim
Patel MK, Mulloy B, Gallagher KL, O'Brien L, Hughes AD. 2002. The antimitogenic action of the sulphated polysaccharide fucoidan differs from heparin in human vascular smooth muscle cells. Thromb Haemost 87: 149-154.
O'Leary R, Rerek M, Wood EJ. 2004. Fucoidan modulates the effect of transforming growth factor (TGF)-beta1 on fibroblast proliferation and wound repopulation in vitro models of dermal wound repair. Biol Pharm Bull 27: 266-270.
Mahony MC, Oehninger S, Clark GF, Acosta AA, Hodgen GD. 1991. Fucoidin inhibits the zona pellucida-induced acrosome reaction in human spermatozoa. Contraception 44: 657-665.
Baba M, Snoeck R, Pauwels R, de Clercq E. 1988. Sulfated polysaccharides are potent and selective inhibitors of various enveloped viruses, including herpes simplex virus, cytomegalovirus, vesicular stomatitis virus, and human immunodeficiency virus. Antim
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[P8-205] Streptozotocin 유도 당뇨 흰쥐의 생식기관에 미치는 Fucoidan의 효과
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Anti-diabetic function of fucoidans extracted from brown seaweeds in Quebec and its structural properties
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