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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.6
- 수록면
- 119 - 125 (7page)
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It is widely known that protein tyrosine kinases (PTKs) are involved in controlling many biological processes such as cell growth, differentiation, proliferation, survival and apoptosis. An α3β4 subunit combination acts as a major functional acetylcholine receptor (nAChRs) in male rat major pelvic ganglion (MPG) neurons, and their activation induces fast inward currents and intracellular calcium increases. Recently it has been reported that the activity of acetylcholine receptors (AChRs) in some neurons can be negatively regulated by PTKs. However, the exact mechanism of regulation of nAChRs by PTKs is poorly understood. Therefore, we examined the potential role particular in nAChR by PTK using electrophysiology and calcium imaging in male rat MPG neurons. ACh induced inward currents and (Ca²?)<SUB>i</SUB> increases in MPG neurons, concomitantly. These responses were inhibited by more than 90% in Na?- or Ca²?- free solution. α-conotoxin AuIB, a selective α3β4 nAChR blocker, inhibited ACh-induced inward currents. Genistein (10 μM), a broad-spectrum tyrosine kinase inhibitor, markedly decreased ACh-induced currents and Ca²? transients, whereas 10 μM genistin, an inactive analogue, had little effect. Overall these data suggest that the activities of α3β4 AChRs in MPG neurons are positively regulated by PTK. In conclusion, tyrosine kinase may be one of the key factors in the regulation of α3β4 nAChRs in rat MPG neurons, which may play an important roles in the autonomic neuronal function such as synaptic transmission, autonomic reflex, and neuronal plasticity.
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