지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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γ-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the central nervous system, and its actions are mediated by subtypes of GABA receptors named as GABA<SUB>A</SUB>, GABA<SUB>B</SUB>, and GABA<SUB>C</SUB>. GABA<SUB>A</SUB>, receptor consisting of α, β, γ and δ subunits is a heterooligomeric ligand-gated chloride channel. This study was performed to investigate regulation of GABA<SUB>A</SUB> receptor by protein kinase C (PKC). Ion currents were recorded using gramicidine-perforated patch and whole cell patch clamp. mRNA encoding the subunits of PKC expressed in major pelvic ganglion (MPG) neurons was detected by using RT-PCR. The GABA-induced inward current was increased by PKC activators and decreased by PKC inhibitors, respectively. These effects were not associated with intracellular Ca²? and OAG (1-oleoyl-2-acetyl-sn-glycerol), a membrane permeable diacylglycerol (DAG) analogue. These results mean that the subfamily of PKC participating in activation of GABA<SUB>A</SUB> receptor would be an atypical PKC (aPKC). Among theses, ξ isoform of aPKC was detected by RT-PCR. Taking together, we suggest that excitable GABA<SUB>A</SUB> receptor in sympathetic MPG neuron seemed to be regulated by aPKC, particular in ξ isoform. The regulatory roles of PKC on excitatory GABA<SUB>A</SUB> receptors in sympathetic neurons of MPG may be an important factor to control the functional activity of various pelvic organs such as bowel movement, micturition and erection.
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