지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.6
- 수록면
- 113 - 118 (6page)
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초록· 키워드
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Major pelvic ganglia (MPG) in rats are an unique autonomic ganglia, containing both sympathetic and parasympathetic neurons related with the function of bladder, penis and bowel. It has been widely Down that ionotropic GABA<sub>A</sub> receptors are the molecular target of γ-aminobutyric acid (GABA), a major inhibitory neurotransmitter in central nervous system. However, their functions and regulations of GABA<sub>A</sub> receptors expressed in autonomic ganglia have been poorly understood. I examined the modulatory role of adenylyl cyclase (AC) and protein kinase A (PKA) on GABA<sub>A</sub>-induced inward currents in the neurons of rat MPG. GABA<sub>A</sub> receptors were identified using immunofluorescent labeling in the rat major pelvic ganglion. Electrophysiological experiments were performed to record the activities of GABA<sub>A</sub> receptors. GABA<sub>A</sub> receptors were expressed only in sympathetic neurons. GABA induced marked inward currents in a concentration-dependent manner. Mucimol (5 μM), a GABA<sub>A</sub> receptor agonist induced inward currents were significantly reduced in the presence of SQ 225361 20 μM, a AC inhibitor and myristoylated PKA inhibitor 100 nM. In addition, forskolin (1 μM), AC activator, augmented the GABA induced currents. The activation of AC/PKA-dependent pathway could involve in the regulation GABA<sub>A</sub> receptors, expressed only in sympathetic neurons of rat MPG. These findings are helpful for the better understanding the function of various pelvic organs innervated by MPG.
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UCI(KEPA) : I410-ECN-0101-2009-510-017357166