지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.12
- 수록면
- 435 - 438 (4page)
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초록· 키워드
오류제보하기
In eukaryotes, ER stress induces UPR (unfolded protein response) via IRE1 activation which sends a molecular signal for XBP1 mRNA splicing in the cytosol. During this mRNA splicing, 23 nt removed in which contains PstI site and then resulting XBP1 product is not digested with PstI restriction enzyme. In this study, using this XBP1 mRNA splicing mechanism, the effect of heat shock on thyrocytes is studied, because heat shock response in the thyrocytes needs more study to understand thyroid physiology under alternative environments. ER inducible drugs (tunicamycin, DTT, Ca²? ionopore A23187, BFA) induce ER stress in the thyrocytes. From 3 hours after heat shock, ER stress is induced and which is reversible when heat shock is without. While Ca²? ionopore A23187 is reversible from ER stress by washing out the drug, thapsigagin is irreversible. Other ER inducible drugs are not so sensitive to ER stress repairing. XBP1 mRNA splicing in a cell is very available method to detect ER stress. It needs only a small quantity of total RNA and processing also very easy.
목차
등록된 정보가 없습니다.
참고문헌 (12)
참고문헌 신청
1. [학술지(정기간행물)] - Benjamin, IJ / 2006 / Viewing a stressful episode of ER: is ATF6 the triage nurse? / Circ Res. 98 : 1120 ~ 1122
2. [학술지(정기간행물)] - Bolte, C / 2003 / Function of HSP90 and p23 in the telomerase complex of thyroid tumoers / Path Res Pract. 199 : 573 ~ 579
3. [학술지(정기간행물)] - DJ DeGracia / 2002 / Molecular pathways of protein synthesis inhibition during brain reperfusion: implications for neuronal survival or death / J Cereb Blood Flow Metab. 22 : 127 ~ 141
4. [학술지(정기간행물)] - de Meis, L / 2002 / Ca2+-ATPases (SERCA): energy transduction and heat production in transport ATPases / J Membr Biol. 188 : 1 ~ 9
5. [학술지(정기간행물)] - Kilgore, JL / 2004 / Severty of viral infection is promoted by hyperthermic pretreatment / J Sci Med Sport. 7 : 259 ~ 263
2. [학술지(정기간행물)] - Bolte, C / 2003 / Function of HSP90 and p23 in the telomerase complex of thyroid tumoers / Path Res Pract. 199 : 573 ~ 579
3. [학술지(정기간행물)] - DJ DeGracia / 2002 / Molecular pathways of protein synthesis inhibition during brain reperfusion: implications for neuronal survival or death / J Cereb Blood Flow Metab. 22 : 127 ~ 141
4. [학술지(정기간행물)] - de Meis, L / 2002 / Ca2+-ATPases (SERCA): energy transduction and heat production in transport ATPases / J Membr Biol. 188 : 1 ~ 9
5. [학술지(정기간행물)] - Kilgore, JL / 2004 / Severty of viral infection is promoted by hyperthermic pretreatment / J Sci Med Sport. 7 : 259 ~ 263
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UCI(KEPA) : I410-ECN-0101-2009-510-017674042