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Involvement of Orai1 in tunicamycin-induced endothelial dysfunction
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논문 기본 정보

Type
Academic journal
Author
Journal
The Korean Society Of Pharmacology The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제23권 제2호 KCI Accredited Journals
Published
2019.1
Pages
95 - 102 (8page)

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Involvement of Orai1 in tunicamycin-induced endothelial dysfunction
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Abstract· Keywords

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Endoplasmic reticulum (ER) stress is mediated by disturbance of Ca2+ homeostasis. The store-operated calcium (SOC) channel is the primary Ca2+ channel in non-excitable cells, but its participation in agent-induced ER stress is not clear. In this study, the effects of tunicamycin on Ca2+ influx in human umbilical vein endothelial cells (HUVECs) were observed with the fluorescent probe Fluo-4 AM. The effect of tunicamycin on the expression of the unfolded protein response (UPR)-related proteins BiP and CHOP was assayed by western blotting with or without inhibition of Orai1. Tunicamycin induced endothelial dysfunction by activating ER stress. Orai1 expression and the influx of extracellular Ca2+ in HUVECs were both upregulated during ER stress. The SOC channel inhibitor SKF96365 reversed tunicamycin-induced endothelial cell dysfunction by inhibiting ER stress. Regulation of tunicamycin-induced ER stress by Orai1 indicates that modification of Orai1 activity may have therapeutic value for conditions with ER stress-induced endothelial dysfunction.

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References (28)

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Xu J / 2009 / Molecular insights and therapeutic targets for diabetic endothelial dysfunction / Circulation 120:1266~1286 google schola Bonetti PO / 2003 / Endothelial dysfunction : a marker of atherosclerotic risk / Arterioscler Thromb Vasc Biol 23:168~175 google schola Lu Y / 2013 / Palmitate induces apoptosis in mouse aortic endothelial cells and endothelial dysfunction in mice fed high-calorie and high-cholesterol diets / Life Sci 92:1165~1173 google schola Gargalovic PS / 2006 / The unfolded protein response is an important regulator of inflammatory genes in endothelial cells / Arterioscler Thromb Vasc Biol 26:2490~2496 google schola Lenna S / 2014 / Endoplasmic reticulum stress and endothelial dysfunction / IUBMB Life 66:530~537 google schola

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