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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.6
- 수록면
- 249 - 252 (4page)
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The mammalian unfolded protein response (UPR) protects the cell against the stress of unfolded or misfolded proteins in the endoplasmic reticulum (ER). It has recently demonstrated that IREI, PERK, ATF6, and X-box protein 1 (XBP-1) directly or indirectly participate in this process. Upon accumulation of unfolded/misfolded. proteins in the ER lumen, release of BiP from Irelp permits dimerization and autophosphorylation to activate its kinase and endoribonulease activities to initiate XBP-1 mRNA splicing. Spliced XBP-1 mRNA removed middle part of 23 bp and encodes a potent transcription factor, XBP-1 protein that binds to the unfolded protein response element (UPRE) or endoplasmic reticulum stress element (ERSE) sequence of many UPR target genes and produces several kind of ER chaperones. In this study, we described both the result and the detailed experimental procedures of XBP-1 mRNA splicing induced by ER stress, this result might help to elucidate the roles of the UPR and early diagnosis in a number of human diseases involving endoplasmic reticulum storage disease (ERSD).
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UCI(KEPA) : I410-ECN-0101-2009-510-017356523