Prognostic Significance of Interactions Between ER Alpha and ER Beta and Lymph Node Status in Breast Cancer Cases

Han, Shu-Jing; Guo, Qing-Qing; Wang, Ting; Wang, You-Xin; Zhang, Yu-Xiang; Liu, Fen; Luo, Yan-Xia; Zhang, Jie; Wang, You-Li; Yan, Yu-Xiang; Peng, Xiao-Xia; Ling, Rui; He, Yan

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저자정보: Han, Shu-Jing (Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University) Guo, Qing-Qing (Beijing Friend Hospital, Capital University of Medical Sciences) Wang, Ting (Departments of General Surgery, Xinjing Hospital, Xi'an) Wang, You-Xin (Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University) Zhang, Yu-Xiang (Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University) Liu, Fen (Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University) Luo, Yan-Xia (Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University) Zhang, Jie (Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University) Wang, You-Li (Peking University People's Hospital) Yan, Yu-Xiang (Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University) Peng, Xiao-Xia (Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University) Ling, Rui (Depart) He, Yan

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제14권 제10호

발행연도: 2013.1

수록면: 6,081 - 6,084 (4page)

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Objective: Both estrogen receptors, ER alpha ($ER{\alpha}$) and ER beta ($ER{\beta}$), are expressed in 50-70% of breast cancer cases. The role of $ER{\alpha}$ as a prognostic marker in breast cancer has been well established as its expression is negative correlated with tumor size and lymph node metastasis. $ER{\beta}$ is also a favorable prognostic predictor although this is less well documented than for $ER{\alpha}$. Materials and Methods: To explore whether ERs independently or together might influence clinical outcome in breast cancer, the correlation between the ERs with the clinicopathological features was analyzed in 84 patients. Results: $ER{\alpha}$ expression negatively correlated with tumor stage (r=-0.246, p=0.028) and tended to be negatively correlated with lymph node status (r=-0.156, p=0.168) and tumor size (r=-0.246, p=0.099). Also, $ER{\beta}$ was negatively correlated with nodal status (r=-0.243, p=0.028), as was coexpression of $ER{\alpha}$ and $ER{\beta}$ (p=0.043, OR=0.194, 95% CI= 0.040-0.953). Conclusion: Coexpression of ERs might serve as an indicator of good prognosis in breast cancer patients.

#Breast cancer #ER alpha #ER beta #interaction #lymph node #metastasis

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Han, Shu-Jing

소속기관 Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical Universit