지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 179 - 185 (7page)
이용수
초록· 키워드
오류제보하기
Objective Metabolic abnormalities, e.g., diabetes, are common among schizophrenia patients. Peroxisome proliferator activated receptor-γ (PPAR-γ) regulates glucose/lipid metabolisms, and schizophrenia like syndrome may be induced by actions involving retinoid X receptor-α/PPAR-γ heterodimers. We examined a possible role of the PPAR-γ gene in metabolic traits and psychosis profile in schizophrenia patients exposed to antipsychotics.
Methods Single nucleotide polymorphisms (SNPs) of the PPAR-γ gene and a serial of metabolic traits were determined in 394 schizophrenia patients, among which 372 were rated with Positive and Negative Syndrome Scale (PANSS).
Results SNP-10, -12, -18, -19, -20 and -26 were associated with glycated hemoglobin (HbA1c) whereas SNP-18, -19, -20 and -26 were associated with fasting plasma glucose (FPG). While SNP-23 was associated with triglycerides, no associations were identified between the other SNPs and lipids. Further haplotype analysis demonstrated an association between the PPAR-γ gene and psychosis profile.
Conclusion Our study suggests a role of the PPAR-γ gene in altered glucose levels and psychosis profile in schizophrenia patients exposed to antipsychotics. Although the Pro12Ala at exon B has been concerned an essential variant in the development of obesity, the lack of association of the variant with metabolic traits in this study should not be treated as impossibility or a proof of error because other factors, e.g., genes regulated by PPAR-γ, may have complicated the development of metabolic abnormalities. Whether the PPAR-γ gene modifies the risk of metabolic abnormalities or psychosis, or causes metabolic abnormalities that lead to psychosis, remains to be examined.
목차
등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Carpenter WT Jr / 2004 / Clinical constructs and therapeutic discovery / Schizophr Res 72 : 69 ~ 73
Chen CH / 2011 / Gender differences in the effects of peroxisome proliferator-activated receptor γ2 gene polymorphisms on metabolic adversity in patients with schizophrenia
Cheng JJ / 1996 / Positive and negative syndrome scale (PANSS): Establishment and reliability study of a mandarin Chinese language version / Chin Psychiaty 10 : 251 ~ 258
Daynes RA / 2002 / Emerging roles of PPARs in inflammation and immunity / Nat Rev Immunol 2 : 748 ~ 759
Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, and Novartis Institutes of BioMedical Research / 2007 / Genomewide association analysis
Chen CH / 2011 / Gender differences in the effects of peroxisome proliferator-activated receptor γ2 gene polymorphisms on metabolic adversity in patients with schizophrenia
Cheng JJ / 1996 / Positive and negative syndrome scale (PANSS): Establishment and reliability study of a mandarin Chinese language version / Chin Psychiaty 10 : 251 ~ 258
Daynes RA / 2002 / Emerging roles of PPARs in inflammation and immunity / Nat Rev Immunol 2 : 748 ~ 759
Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, and Novartis Institutes of BioMedical Research / 2007 / Genomewide association analysis
이 논문의 저자 정보
최근 본 자료
댓글(0)
0