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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Journal of Food Science and Nutrition Journal of Food Science and Nutrition Vol.2 No.1
- 발행연도
- 1997.3
- 수록면
- 49 - 54 (6page)
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The modifying effects of Chelidonium mojus L.(Papaveracea) herb extract(CH), an analgesic traditionally prescribed for gastric and duodenal ulcer patients, on gastric tumor development given N-methyl-N'-nitro?N-nitrosoguanidine(MNNG) were studied in sixty-four 6-week-old male Wistar rats. Group 1 rats were initially given MNNG(200mg/kg b.w.) by gavage at days 0 and 14 as well as saturated sodium chloride solution (S-NaCl, 1ml per rat) every 3 days during weeks 0 to 3(6 times), and then placed on basal diet containing 0.1 or 0.2% CH for 16 weeks from week 4. Rats of Groups 2 and 3 were treated with MNNG together with S-NaCl or saline(0.9% NaCl, 1ml per rat) respectively, timed as in Group 1 but without further treatment. All survival animals were killed at week 20 and histopathologically investigated. In the glandular stomach, the number of preneoplastic pepsinogen 1 altered pyloric glands(PAPGs) in the MNNG+S-NaCl→CH(0.1%) group(Group 1) was significantly smaller than in the MNNG+S-NaCl group(Group 2)(p<0.02). The incidences of forestomach neoplastic lesions(papillomas and squamous cell carcinomas) also showed a tendency for decrease with the CH treatment. The results thus indicate that CH exerts inhibitory effects on glandular stomach carcinogenesis in the rat, so that it may have potential as a chemopreventive agent for stomach cancer in man.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
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