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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.3
- 수록면
- 320 - 330 (11page)
- DOI
- 10.14348/molcells.2018.2292
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초록· 키워드
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δ-Catenin, a member of the p120-catenin subfamily of armadillo proteins, reportedly increases during the late stage of prostate cancer. Our previous study demonstrates that δ-catenin increases the stability of EGFR in prostate cancer cell lines. However, the molecular mechanism behind δ-catenin-mediated enhanced stability of EGFR was not explored. In this study, we hypothesized that δ-catenin enhances the protein stability of EGFR by inhibiting its lysosomal degradation that is mediated by c-casitas b-lineage lymphoma (c-Cbl), a RING domain E3 ligase. c-Cbl monoubiquitinates EGFR and thus facilitates its internalization, followed by lysosomal degradation. We observed that δ-catenin plays a key role in EGFR stability and downstream signaling. δ-Catenin competes with c-Cbl for EGFR binding, which results in a reduction of binding between c-Cbl and EGFR and thus decreases the ubiquiti-nation of EGFR. This in turn increases the expression of membrane bound EGFR and enhances EGFR/Erk1/2 sig-naling. Our findings add a new perspective on the role of δ-catenin in enhancing EGFR/Erk1/2 signaling-mediated prostate cancer.
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등록된 정보가 없습니다.
참고문헌 (41)
참고문헌 신청
Anastasiadis, P.Z. / 2000 / The p120 catenin family:complex roles in adhesion, sinalign and cancer / J. Cell Sci. 113:1319~1334
Burger, M.J. / 2002 / Expression analysis of delta-catenin and prostate-specific membrane antigen: their potential as diagnostic markers for prostate cancer / Int. J. Cancer 100:228~237
de Melker, A.A. / 2001 / c-Cbl ubiquitinates the EGF receptor at the plasma membrane and remains receptor associated throughout the endocytic route / J. Cell Sci. 114:2167~2178
Di Lorenzo, G. / 2002 / Expression of epidermal growth factor receptor correlates with disease relapse and progression to androgen-independence in human prostate cancer / Clin. Cancer Res. 8:3438~3444
Franovic, A. / 2007 / Translational up-regulation of the EGFR by tumor hypoxia provides a nonmutational explanation for its overexpression in human cancer / Proc. Natl. Acad. Sci. USA 104:13092~13097
Burger, M.J. / 2002 / Expression analysis of delta-catenin and prostate-specific membrane antigen: their potential as diagnostic markers for prostate cancer / Int. J. Cancer 100:228~237
de Melker, A.A. / 2001 / c-Cbl ubiquitinates the EGF receptor at the plasma membrane and remains receptor associated throughout the endocytic route / J. Cell Sci. 114:2167~2178
Di Lorenzo, G. / 2002 / Expression of epidermal growth factor receptor correlates with disease relapse and progression to androgen-independence in human prostate cancer / Clin. Cancer Res. 8:3438~3444
Franovic, A. / 2007 / Translational up-regulation of the EGFR by tumor hypoxia provides a nonmutational explanation for its overexpression in human cancer / Proc. Natl. Acad. Sci. USA 104:13092~13097
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