지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.8
- 수록면
- 1,691 - 1,702 (12page)
- DOI
- 10.1038/s12276-024-01282-3
이용수
초록· 키워드
오류제보하기
Although the role of gut microbiota (GMB)-derived metabolites in mitochondrial and endolysosomal dysfunction in Alzheimer’s disease (AD) under metabolic syndrome remains unclear, deciphering these host–metabolite interactions represents a major public health challenge. Dysfunction of mitochondria and endolysosomal networks (ELNs) plays a crucial role in metabolic syndrome and can exacerbate AD progression, highlighting the need to study their reciprocal regulation for a better understanding of how AD is linked to metabolic syndrome. Concurrently, metabolic disorders are associated with alterations in the composition of the GMB. Recent evidence suggests that changes in the composition of the GMB and its metabolites may be involved in AD pathology. This review highlights the mechanisms of metabolic syndrome-mediated AD development, focusing on the interconnected roles of mitochondrial dysfunction, ELN abnormalities, and changes in the GMB and its metabolites. We also discuss the pathophysiological role of GMB-derived metabolites, including amino acids, fatty acids, other metabolites, and extracellular vesicles, in mediating their effects on mitochondrial and ELN dysfunction. Finally, this review proposes therapeutic strategies for AD by directly modulating mitochondrial and ELN functions through targeting GMB metabolites under metabolic syndrome.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Emerging perspectives on mitochondrial dysfunction and inflammation in Alzheimer’s disease
BMB Reports
2020 .01
-
The role of cell type-specific mitochondrial dysfunction in the pathogenesis of Alzheimer’s disease
BMB Reports
2019 .01
-
Mitochondrial dysfunction and Alzheimer’s disease: prospects for therapeutic intervention
BMB Reports
2020 .01
-
한국인유전체역학조사사업 자료를 활용한 대사증후군 관련 대사체 연구 동향: 스코핑 리뷰
KSBB Journal
2025 .03
-
Systems Metabolic Engineering for the Enhanced Production of Secondary Metabolites
한국생물공학회 학술대회
2022 .09
-
Metabolic flux between organs measured by arteriovenous metabolite gradients
Experimental and Molecular Medicine
2022 .09
-
Bioactive Microbiota Metabolites in The Mouse Gut
한국생물공학회 학술대회
2017 .04
-
농촌지역 주민의 대사증후군 발생률과 위험요인
한국산학기술학회 논문지
2015 .06
-
Prediction of Metabolites Heavily Used in Cancer-associated Fibroblasts Using Their Genome-scale Metabolic Models for Effective Cancer Treatment
한국생물공학회 학술대회
2022 .04
-
Poly-(γ-D-Glutamic Acid) Ameliorates Metabolic Dysfunction by Modulating Metabolic Gene Expression and Attenuating Intestinal Barrier Injury
한국생물공학회 학술대회
2022 .09
-
Current understanding of the Alzheimer’s disease-associated microbiome and therapeutic strategies
Experimental and Molecular Medicine
2024 .01
-
Metabolic features and regulation in cell senescence
BMB Reports
2019 .01
-
청소년의 대사증후군 유병률 및 관련요인
한국산학기술학회 논문지
2018 .03
-
The gut microbiota: a key regulator of metabolic diseases
BMB Reports
2016 .01
-
Systematic Prediction of Metabolites and Metabolic Pathways Associated with Somatic Mutations in Cancers Using Genome-scale Metabolic Models
한국생물공학회 학술대회
2023 .10
-
A Meta-Analysis on the Metabolic Syndrome Risk Factors using Big Data Analysis
INTERNATIONAL CONFERENCE ON FUTURE INFORMATION & COMMUNICATION ENGINEERING
2016 .06
-
Stress Adaptation of Escherichia coli as Monitored via Metabolites by Using Two-Dimensional NMR Spectroscopy
Journal of the Korean Magnetic Resonance Society
2017 .01
-
Genome-scale Metabolic Modeling for the Prediction of Metabolites in Cancer-associated Fibroblasts That Can Affect the Growth of Interacting Cancer Cells
한국생물공학회 학술대회
2023 .04
-
Role of Gut Metabolites in the Regulation of intestinal immunity
한국생물공학회 학술대회
2020 .10
-
Molecular cross talkamongthecomponentsofthe regulatory machinery of mitochondrial structure and quality control
Experimental and Molecular Medicine
2020 .01
최근 본 자료
댓글(0)
0