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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 536 - 541 (6page)
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초록· 키워드
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The prevalence of obesity and type 2 diabetes, two closely linked metabolic disorders, is increasing worldwide. Over the past decade, the connection between these disorders and the microbiota of the gut has become a major focus of biomedical research, with recent studies demonstrating the fundamental role of intestinal microbiota in the regulation and pathogenesis of metabolic disorders. Because of the complexity of the microbiota community, however, the underlying molecular mechanisms by which the gut microbiota is associated with metabolic disorders remain poorly understood. In this review, we summarize recent studies that investigate the role of the microbiota in both human subjects and animal models of disease and discuss relevant therapeutic targets for future research.
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참고문헌 (62)
참고문헌 신청
Qin J / 2010 / A human gut microbial gene catalogue established by metagenomic sequencing / Nature 464:59~65
Human Microbiome Project C / 2012 / Structure, function and diversity of the healthy human microbiome / Nature 486:207~214
Belkaid Y / 2014 / Role of the microbiota in immunity and inflammation / Cell 157:121~141
Sonnenburg JL / 2016 / Diet-microbiota interactions as moderators of human metabolism / Nature 535:56~64
Tremaroli V / 2012 / Functional interactions between the gut microbiota and host metabolism / Nature 489:242~249
Human Microbiome Project C / 2012 / Structure, function and diversity of the healthy human microbiome / Nature 486:207~214
Belkaid Y / 2014 / Role of the microbiota in immunity and inflammation / Cell 157:121~141
Sonnenburg JL / 2016 / Diet-microbiota interactions as moderators of human metabolism / Nature 535:56~64
Tremaroli V / 2012 / Functional interactions between the gut microbiota and host metabolism / Nature 489:242~249
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