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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 5 - 12 (8page)
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초록· 키워드
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Organismal aging is accompanied by a host of progressive metabolic alterations and an accumulation of senescent cells, along with functional decline and the appearance of multiple diseases. This implies that the metabolic features of cell senescence may contribute to the organism’s metabolic changes and be closely linked to age-associated diseases, especially metabolic syndromes. However, there is no clear understanding of senescent metabolic characteristics. Here, we review key metabolic features and regulators of cellular senescence, focusing on mitochondrial dysfunction and anabolic deregulation, and their link to other senescence phenotypes and aging. We further discuss the mechanistic involvement of the metabolic regulators mTOR, AMPK, and GSK3, proposing them as key metabolic switches for modulating senescence.
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등록된 정보가 없습니다.
참고문헌 (95)
참고문헌 신청
Lopez-Otin C / 2013 / The hallmarks of aging / Cell 153:1194~1217
Munoz-Espin D / 2014 / Cellular senescence : from physiology to pathology / Nat Rev Mol Cell Biol 15:482~496
Hernandez-Segura A / 2018 / Hallmarks of Cellular Senescence / Trends Cell Biol 28:436~453
Hanks S / 2004 / Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B / Nat Genet 36:1159~1161
Baker DJ / 2016 / Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan / Nature 530:184~189
Munoz-Espin D / 2014 / Cellular senescence : from physiology to pathology / Nat Rev Mol Cell Biol 15:482~496
Hernandez-Segura A / 2018 / Hallmarks of Cellular Senescence / Trends Cell Biol 28:436~453
Hanks S / 2004 / Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B / Nat Genet 36:1159~1161
Baker DJ / 2016 / Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan / Nature 530:184~189
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