지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 47 - 55 (9page)
이용수
초록· 키워드
오류제보하기
Alzheimer’s disease (AD) is a multifactorial neurodegenerative disease and has become a major socioeconomic issue in many developed countries. Currently available therapeutic agents for AD provide only symptomatic treatments, mainly because the complete mechanism of the AD pathogenesis is still unclear. Although several different hypotheses have been proposed, mitochondrial dysfunction has gathered interest because of its profound effect on brain bioenergetics and neuronal survival in the pathophysiology of AD. Various therapeutic agents targeting the mitochondrial pathways associated with AD have been developed over the past decade. Although most of these agents are still early in the clinical development process, they are used to restore mitochondrial function, which provides an alternative therapeutic strategy that is likely to slow the progression of the disease. In this mini review, we will survey the AD-related mitochondrial pathways and their small-molecule modulators that have therapeutic potential. We will focus on recently reported examples, and also overview the current challenges and future perspectives of ongoing research.
목차
등록된 정보가 없습니다.
참고문헌 (84)
참고문헌 신청
Anand R / 2014 / Therapeutics of Alzheimer's disease : Past, present and future / Neuropharmacology 76(Pt A):27~50
Perry G / 2000 / Oxidative damage in Alzheimer's disease : the metabolic dimension / Int J Dev Neurosci 18:417~421
Schmitt K / 2012 / Insights into mitochondrial dysfunction : aging, amyloid-beta, and tau-A deleterious trio / Antioxid Redox Signal 16:1456~1466
Yao J / 2009 / Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease / Proc Natl Acad Sci U S A 106:14670~14675
Swerdlow RH / 2010 / The Alzheimer's disease mitochondrial cascade hypothesis / J Alzheimers Dis 20 Suppl 2:S265~279
Perry G / 2000 / Oxidative damage in Alzheimer's disease : the metabolic dimension / Int J Dev Neurosci 18:417~421
Schmitt K / 2012 / Insights into mitochondrial dysfunction : aging, amyloid-beta, and tau-A deleterious trio / Antioxid Redox Signal 16:1456~1466
Yao J / 2009 / Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease / Proc Natl Acad Sci U S A 106:14670~14675
Swerdlow RH / 2010 / The Alzheimer's disease mitochondrial cascade hypothesis / J Alzheimers Dis 20 Suppl 2:S265~279
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Emerging perspectives on mitochondrial dysfunction and inflammation in Alzheimer’s disease
BMB Reports
2020 .01
-
The role of cell type-specific mitochondrial dysfunction in the pathogenesis of Alzheimer’s disease
BMB Reports
2019 .01
-
Molecular cross talkamongthecomponentsofthe regulatory machinery of mitochondrial structure and quality control
Experimental and Molecular Medicine
2020 .01
-
Application of Mitochondrial Transplantation Method in Various Indications
한국생물공학회 학술대회
2024 .09
-
생성적 적대 신경망 기반의 3D 뇌 영상을 이용한 알츠하이머 질병 예측 모델
대한전자공학회 학술대회
2023 .06
-
Single-cell RNA sequencing reveals B cell?related molecular biomarkers for Alzheimer’s disease
Experimental and Molecular Medicine
2021 .12
-
The coordinated regulation of mitochondrial structure and function by Drp1 for mitochondrial quality surveillance
BMB Reports
2019 .01
-
멀티오믹스 데이터를 활용한 알츠하이머 질병 예측 딥러닝 모델 개발 연구
한국정보기술학회논문지
2022 .07
-
Peripheral inflammatory biomarkers in Alzheimer’s disease: a brief review
BMB Reports
2020 .01
-
Current understanding of the Alzheimer’s disease-associated microbiome and therapeutic strategies
Experimental and Molecular Medicine
2024 .01
-
Deep and Statistical-Based Methods for Alzheimer’s Disease Detection: A Survey
Journal of Computing Science and Engineering
2022 .03
-
Optimizing Content Duration for Mobile Ads
IEIE Transactions on Smart Processing & Computing
2016 .08
-
The role of mitochondrial DNA mutation on neurodegenerative diseases
Experimental and Molecular Medicine
2015 .01
-
Techniques for investigating mitochondrial gene expression
BMB Reports
2020 .01
-
Stem cell therapy for Alzheimer’s disease and related disorders: current status and future perspectives
Experimental and Molecular Medicine
2015 .01
-
Mitochondrial dysfunction suppresses p53 expression via calcium-mediated nuclear factor-kB signaling in HCT116 human colorectal carcinoma cells
BMB Reports
2018 .01
-
An Implementation of Effective CNN Model for AD Detection
스마트미디어저널
2024 .06
-
Diagnosis of Alzheimer "s Disease using Combined Featur e Selection Method
멀티미디어학회논문지
2021 .05
-
경기도 초등학교 학생수 변화 경향에 대한 조사 연구
교육녹색환경연구
2021 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0