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논문 기본 정보

자료유형
학술저널
저자정보
Min-Jeong Kang (Kyungpook National University) Nang Paung Li (Kyungpook National University) Hyunseung Hong (Seoul National University) Hyo-Sang Park (Kyungpook National University) Ji Wan Park (Hallym University College of Medicine) Marie M. Tolarova (University of the Pacific) Il-Hyung Yang (Seoul National University) Mihee Hong (Kyungpook National University) Seung-Hak Baek (Seoul National University)
저널정보
대한치과교정학회 대한치과교정학회지 대한치과교정학회지 제54권 제6호
발행연도
2024.11
수록면
411 - 421 (11page)

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초록· 키워드

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Objective: To investigate which types of environmental exposure during pregnancy are risk and protective factors for cleft lip with or without cleft palate (CL/P). Methods: This case-control study included 278 orthodontic patients with CL/P (CL/P group) and 51 without CL/P (non-CL/P group). Demographic and environmental exposure data were collected using questionnaires completed by the parents. Statistical analyses were performed to identify the potential risk and protective factors for CL/P. Results: The two groups did not show significant difference in (1) body weight at birth and number of previous births; (2) fathers’ ages at birth and occupation; (3) parents’ chronic diseases, alcohol consumption, and exposure to harmful substances; and (4) mothers’ smoking, secondhand smoking, and vitamin and calcium intake. Most patients with CL/P were born at normal term (≥ 37 weeks, 93.2%) with normal body weight (2.9–3.7 ㎏, 63.7%) and as either the first or second child (90.3%). In the CL/P group, the percentages of mothers who were very young or old (≤ 19 years, ≥ 40 years) and with physical labor in their occupation were low (1.8% and 2.2%, respectively). Compared with the non-CL/P group, the CL/P group showed a lower percentage of maternal folic acid intake (68.6% vs. 20.9%, odds ratio [OR] = 0.121; P < 0.001) and higher percentages of mothers’ drug intake and fathers’ smoking habits (3.9% vs. 16.2%, OR = 4.73, P < 0.05; 39.2% vs. 61.2%, OR = 2.44, P < 0.01). Conclusions: The findings of this study may explain the association between environmental factors and CL/P risk.

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INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
CONCLUSIONS
REFERENCES

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