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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 충북대학교 동물의학연구소 Journal of Biomedical and Translational Research Journal of Biomedical and Translational Research 제22권 제3호
- 발행연도
- 2021.9
- 수록면
- 111 - 120 (10page)
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초록· 키워드
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Colon cancer has been considered a leading cause of cancer-associated death. Folic acid is a vitamin necessary for cellular physiological functions and cell viability. However, the asso ciation between folic acid intake and colon cancer has been examined in several prospective cohort studies are controversial. This study investigated the effects of folate intake on colon carcinogenesis and oxidative stress in an azoxymethane (AOM)/dextran sodium sulfate (DSS) institute for cancer research (ICR) mouse model. Thirty male ICR mice (5 weeks old) were di vided into the control group and the experimental group supplied 0.03% folic acid via drinking water (50 mL/week/mouse) for 6 weeks. To induce colonic pre-neoplastic lesions, the animals were subcutaneously injected three times weekly with AOM (10 mg/kg body weight), followed by 2% DSS in drinking water for a week. Folic acid supplementation significantly suppressed the total number of aberrant crypt foci and aberrant crypts. Histological image data showed that folic acid supplementation attenuated neoplastic change. In addition, we measured the thiobarbituric acid reactive substances concentration of dry feces samples to identify the ef fect of folic acid on reactive oxygen accumulation. The folic acid supplementation group had reduced reactive oxygen species levels in dry feces compared to the control group. In con clusion, these findings indicate that folic acid suppresses colon carcinogenesis and oxidative stress in an AOM/DSS mouse model.
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참고문헌 (33)
참고문헌 신청
Seiwert N / 2020 / Mechanism of colorectal carcinogenesis triggered by heme iron from red meat / Biochim Biophys Acta Rev Cancer 1873:188334
Peto J / 2001 / Cancer epidemiology in the last century and the next decade / Nature 411:390~395
Gamage SMK / 2018 / The role of heme iron molecules derived from red and processed meat in the pathogenesis of colorectal carcinoma / Crit Rev Oncol Hematol 126:121~128
Wiseman M / 2008 / The second World Cancer Research Fund/American Institute for Cancer Research expert report. Food, nutrition, physical activity, and the prevention of cancer: a global perspective / Proc Nutr Soc 67:253~256
Ronellenfitsch U / 2009 / Stomach cancer mortality in two large cohorts of migrants from the Former Soviet Union to Israel and Germany : are there implications for prevention / Eur J Gastroenterol Hepatol 21:409~416
Peto J / 2001 / Cancer epidemiology in the last century and the next decade / Nature 411:390~395
Gamage SMK / 2018 / The role of heme iron molecules derived from red and processed meat in the pathogenesis of colorectal carcinoma / Crit Rev Oncol Hematol 126:121~128
Wiseman M / 2008 / The second World Cancer Research Fund/American Institute for Cancer Research expert report. Food, nutrition, physical activity, and the prevention of cancer: a global perspective / Proc Nutr Soc 67:253~256
Ronellenfitsch U / 2009 / Stomach cancer mortality in two large cohorts of migrants from the Former Soviet Union to Israel and Germany : are there implications for prevention / Eur J Gastroenterol Hepatol 21:409~416
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