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논문 기본 정보

자료유형
학술저널
저자정보
Dong Yoon Kim (Sunchon National University) Soo-Sung Kim (Sunchon National University) Eun-Jin Choi (Sunchon National University) Hoon Kim (NANUMBIO) Dong Hyeon Kim (NANUMBIO) Seong-Min Hong (Gachon University) Sae-Byuk Lee (Kyungpook National University) Hyun-Dong Cho (Sunchon National University)
저널정보
한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.29 No.4
발행연도
2024.12
수록면
474 - 484 (11page)

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초록· 키워드

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Inflammatory bowel disease, including Crohn’s disease and ulcerative colitis, poses an emerging threat as it can lead to colorectal cancer, thrombosis, and other chronic conditions. The present study demonstrated the protective effects of peanut sprout extracts (PSEs) prepared from day 2 to day 7 of germination against lipopolysaccharide (LPS)-induced epithelial barrier breakdown. Although the peanut sprout length increased in a time-dependent manner from day 1 to day 7, the extraction yields remained relatively consistent from day 2 to day 7. With regard to antioxidant activities, the PSE from day 6 of germination exhibited the highest oxidative radical scavenging activity and total phenolic content. Similarly, it showed remarkable anti-permeability effects in LPS-stimulated Caco-2 cells and suppressed the degradation and dissociation of junctional markers (e.g., ZO-1 and E-cadherin) at cell-cell junctions. Collectively, these data demonstrate that PSE from day 6 of germination can be used as a functional food resource to reduce inflammatory barrier dysfunction.

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ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
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