지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.11
- 수록면
- 543 - 551 (9page)
이용수
초록· 키워드
오류제보하기
Background: Ginsenoside, as an active ingredient in traditional Chinese medicine, has been widely used for skin whitening for several years. Recent research has found that Panax notoginseng has a higher content of ginsenosides compared with the Panax ginseng. Those ginsenosides have promising potential to be developed as skin whitening agents.
Methods: We selected five dammarane ginsenosides isolated from P. notoginseng and their mixtures to investigate the skin lightning activity. Zebrafish embryo model was used for initial screening of the whitening activity. Subsequently, the whitening effect of components was examined and compared via testing the inhibition of melanin and activity of tyrosinase in B16 cells treated with these components. Molecular docking was also applied to investigate the interactions between ginsenosides and tyrosinase. Finally, the most effective saponins were selected for dosage form optimization and the whitening effect of saponin-loaded ethosomes was further demonstrated on the C57BL/6 mouse model.
Results: Experimental results showed that the protopanaxtriol saponins (PTS) were the most potent saponins with a decent safety profile, and the molecule docking results demonstrated that PTS had strong inhibitory ability to tyrosinase. PTS was successfully encapsulated into ethosomes with an encapsulation efficiency of 93%. The PTS ethosome gel could effectively inhibit the melanin production caused by UVB tanning on the back skin of mice.
Conclusion: The PTS ethosome gel provides an effective and safe formulation of PTS to whiten the UVB-tanned skin in vivo and could be used as a potential skin whitening agent in the future.
Methods: We selected five dammarane ginsenosides isolated from P. notoginseng and their mixtures to investigate the skin lightning activity. Zebrafish embryo model was used for initial screening of the whitening activity. Subsequently, the whitening effect of components was examined and compared via testing the inhibition of melanin and activity of tyrosinase in B16 cells treated with these components. Molecular docking was also applied to investigate the interactions between ginsenosides and tyrosinase. Finally, the most effective saponins were selected for dosage form optimization and the whitening effect of saponin-loaded ethosomes was further demonstrated on the C57BL/6 mouse model.
Results: Experimental results showed that the protopanaxtriol saponins (PTS) were the most potent saponins with a decent safety profile, and the molecule docking results demonstrated that PTS had strong inhibitory ability to tyrosinase. PTS was successfully encapsulated into ethosomes with an encapsulation efficiency of 93%. The PTS ethosome gel could effectively inhibit the melanin production caused by UVB tanning on the back skin of mice.
Conclusion: The PTS ethosome gel provides an effective and safe formulation of PTS to whiten the UVB-tanned skin in vivo and could be used as a potential skin whitening agent in the future.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results and discussion
4. Conclusion
References
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
레스베라트롤을 함유한 나노 에토좀 제조에 관한 연구
대한화장품학회지
2015 .01
-
Visualizing the distributions and spatiotemporal changes of metabolites in Panax notoginseng by MALDI mass spectrometry imaging
Journal of Ginseng Research
2021 .11
-
Anti-inflammatory and Immunosuppressive Effects of Panax notoginseng
Natural Product Sciences
2019 .12
-
The potential of Panax notoginseng against COVID-19 infection
Journal of Ginseng Research
2023 .09
-
매니큐어 형태의 과산화수소배합 신종 미백젤의 치아미백 효과
대한구강보건학회지
2019 .01
-
Stem-leaves of Panax as a rich and sustainable source of less-polar ginsenosides: comparison of ginsenosides from Panax ginseng, American ginseng and Panax notoginseng prepared by heating and acid treatment
Journal of Ginseng Research
2021 .01
-
Investigating chemical features of Panax notoginseng based on integrating HPLC fingerprinting and determination of multiconstituents by single reference standard
Journal of Ginseng Research
2018 .06
-
Endophytic fungi harbored in Panax notoginseng : diversity and potential as biological control agents against host plant pathogens of root-rot disease
Journal of Ginseng Research
2017 .07
-
Rhizospheric fungi of Panax notoginseng: diversity and antagonism to host phytopathogens
Journal of Ginseng Research
2016 .04
-
The skin protective effects of compound K, a metabolite of ginsenoside Rb1 from Panax ginseng
Journal of Ginseng Research
2018 .04
-
Pitfalls in the 2017 TNM Classification of Thyroid Carcinoma
The Journal of Endocrine Surgery
2018 .01
-
Analysis of common and characteristic actions of Panax ginseng and Panax notoginseng in wound healing based on network pharmacology and meta-analysis
Journal of Ginseng Research
2023 .07
-
A Genomic Approach to Identify the Different between Acute and Chronic UVB Exposures in the Causation of Inflammation and Cancer
대한암예방학회지
2022 .12
-
Factors Related with Survival and Recurrence of Node-negative pT3 and pT4a Gastric Cancer
대한임상종양학회 학술대회지
2015 .02
-
Diversity, distribution, and antagonistic activities of rhizobacteria of Panax notoginseng
Journal of Ginseng Research
2016 .04
-
Study on the grading standard of Panax notoginseng seedlings
Journal of Ginseng Research
2018 .04
-
Potential of nanoparticulate carriers for improved drug delivery via skin
Journal of Pharmaceutical Investigation
2019 .01
-
The effect of gender, age, and body mass index on the?medial and lateral posterior tibial slopes: a magnetic resonance imaging study
Knee Surgery and Related Research
2021 .01
-
Skin whitening and anti-wrinkle activities of white rose petal extracts
한국실험동물학회 학술발표대회 논문집
2016 .08
-
Ginsenosides repair UVB-induced skin barrier damage in BALB/c hairless mice and HaCaT keratinocytes
Journal of Ginseng Research
2022 .01
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-151-25-02-092095290