Analysis of common and characteristic actions of Panax ginseng and Panax notoginseng in wound healing based on network pharmacology and meta-analysis

Zhen Wang; Xueheng Xie; Mengchen Wang; Meng Ding; Shengliang Gu; Xiaoyan Xing; Xiaobo Sun

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자료유형: 학술저널

저자정보: Zhen Wang (Chinese Academy of Medical Sciences and Peking Union Medical College) Xueheng Xie (Chinese Academy of Medical Sciences and Peking Union Medical College) Mengchen Wang (Chinese Academy of Medical Sciences and Peking Union Medical College) Meng Ding (Chinese Academy of Medical Sciences and Peking Union Medical College) Shengliang Gu (Chinese Academy of Medical Sciences and Peking Union Medical College) Xiaoyan Xing (Chinese Academy of Medical Sciences and Peking Union Medical College) Xiaobo Sun (Chinese Academy of Medical Sciences and Peking Union Medical College)

저널정보: 고려인삼학회 Journal of Ginseng Research Journal of Ginseng Research Vol.47 No.4

발행연도: 2023.7

수록면: 493 - 505 (13page)

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연구주제

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연구배경

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연구방법

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연구결과

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In recent years, an increasing number of reports have explored the wound healing mechanism of these two traditional Chinese herbal medicines- Panax ginseng and Panax notoginseng, but there is no systematic research on the related core functions and different mechanisms in the treatment of wound healing up to now. Based on network pharmacology and meta-analysis, the present work aimed to comprehensively review the commonality and diversity of P. ginseng and P. notoginseng in wound healing. In this study, a wound healing-related “ingredients-targets” network of two herbs was constructed. Thereafter, meta-analysis of the multiple target lists by Metascape showed that these two medicines significantly regulated blood vessel development, responses to cytokines and growth factors and oxygen levels, cell death, cell proliferation and differentiation, and cell adhesion. To better understand the discrepancy between these two herbs, it was found that common signaling pathways including Rap1, PI3K/AKT, MAPK, HIF-1 and Focal adhesion regulated the functions listed above. In parallel, the different pathways including renin-angiotensin system, RNA transport and circadian rhythm, autophagy, and the different metabolic pathways may also explained the discrepancies in the regulation of the above-mentioned functions, consistent with the Traditional Chinese Medicine theory about the effects of P. ginseng and P. notoginseng.

#Wound healing #Network pharmacology #Meta-analysis #Panax ginseng #Panax notoginseng

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