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논문 기본 정보

자료유형
학술저널
저자정보
Yoon Sunghyun (Graduate School of Public Health, Seoul National University, Seoul 08826, Republic of Korea) Park SungJun (N-Bio, Seoul National University, Seoul 08826, Republic of KoreaKoBioLabs, Inc., Seoul 08826, Republic of KoreaweBiom Inc., Seoul 08826, Republic of Korea) Jung Seong Eun (N-Bio, Seoul National University, Seoul 08826, Republic of Korea) Lee Cheonghoon (Graduate School of Public Health, Seoul National University, Seoul 08826, Republic of KoreaInstitute of Health and Environment, Seoul National University, Seoul 08826, Republic of Korea) Kim Woon-Ki (Graduate School of Public Health, Seoul National University, Seoul 08826, Republic of KoreaInstitute of Health and Environment, Seoul National University, Seoul 08826, Republic of Korea) Choi Il-Dong (R&BD Center, hy Co., Ltd., Yongin 17086, Republic of Korea) Ko GwangPyo (Graduate School of Public Health, Seoul National University, Seoul 08826, Republic of KoreaN-Bio, Seoul National University, Seoul 08826, Republic of KoreaKoBioLabs, Inc., Seoul 08826, Repub)
저널정보
한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology Vol.34 No.6
발행연도
2024.6
수록면
1,299 - 1,306 (8page)
DOI
10.4014/jmb.2401.01012

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Antibiotics are used to control infectious diseases. However, adverse effects of antibiotics, such as devastation of the gut microbiota and enhancement of the inflammatory response, have been reported. Health benefits of fermented milk are established and can be enhanced by the addition of probiotic strains. In this study, we evaluated effects of fermented milk containing Lacticaseibacillus rhamnosus (L. rhamnosus) SNUG50430 in a mouse model with antibiotic treatment. Fermented milk containing 2 × 105 colony-forming units of L. rhamnosus SNUG50430 was administered to six weekold female BALB/c mice for 1 week. Interleukin (IL)-10 levels in colon samples were significantly increased (P < 0.05) compared to water-treated mice, whereas interferon-gamma (IFN-γ) and tumor necrosis factor alpha (TNF-α) were decreased, of mice treated with fermented milk containing L. rhamnosus SNUG50430-antibiotics-treated (FM+LR+Abx-treated) mice. Phylum Firmicutes composition in the gut was restored and the relative abundances of several bacteria, including the genera Coprococcus and Lactobacillus, were increased in FM+LR+Abx-treated mice compared to PBS+Abxtreated mice. Interestingly, abundances of genus Coprococcus and Lactobacillus were positively correlated with IL-5 and IL-10 levels (P < 0.05) in colon samples and negative correlated with IFN-γ and TNF-α levels in serum samples (P < 0.001). Acetate and butyrate were increased in mice with fermented milk and fecal microbiota of FM+LR+Abx-treated mice were highly enriched with butyrate metabolism pathway compared to water-treated mice (P < 0.05). Thus, fermented milk containing L. rhamnosus SNUG50430 was shown to ameliorate adverse health effects caused by antibiotics through modulating immune responses and the gut microbiota.

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