지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 환경독성보건학회 Environmental Analysis Health and Toxicology Environmental Analysis Health and Toxicology Vol.39 No.2
- 발행연도
- 2024.6
- 수록면
- 101 - 117 (17page)
이용수
초록· 키워드
오류제보하기
Chronic exposure to glyphosate-based herbicide (Gly) has been associated with neurological disorders. Tannic acid (TA) is an antioxidant with attenuating action against neuroinflammation-associated conditions. This study evaluated the effect of Gly on pain perception alongside antinociceptive and anti-inflammatory actions of TA in Gly-exposed mice. Male Swiss mice were randomly divided into six groups (n=8): control (distilled water 0.2 ml/kg), Gly (Gly 500 mg/kg), Pre-TA + Gly (TA 50 mg/kg pre-treatment, afterwards Gly-administered), TA + Gly (TA 50 mg/kg and Gly co-administered), Pre-AA + Gly (ascorbic acid (AA) 10 mg/kg pre-treatment, afterwards Gly-administered), and AA + Gly (AA 10 mg/kg and Gly co-administered). Mechanical, thermal, and chemical pain were evaluated six weeks post vehicle/drugs administrations orally, followed by brain biochemical measurements. TA treatment alleviated Gly-induced hyperalgesia in similar version to the values of control and AA groups by increasing significantly (p < 0.05) nociceptive thresholds. Moreover, TA-treatment significantly decreased malondialdehyde (MDA) and pro-inflammatory cytokines (TNF-α, IL-1β, and IL-6) levels, significantly increased anti-inflammatory cytokines (IL-10, IL-4, and TGF-1β) levels, and antioxidant enzymes, catalase (CAT), glutathione peroxidase (GPx), and superoxide dismutase (SOD) activities compared to Gly-treated mice (p < 0.05). Conclusively, TA treatment exerted antinociceptive and anti-inflammatory actions, possibly through its antioxidant and anti-inflammatory actions in Gly-exposed mice. Notably, TA pre-treatment showed a better response than TA and Gly co-administration. We propose the potential neuroprotective and ameliorative functions of TA in Gly-induced hyperalgesia. This merits further clinical research into protective roles of TA against pesticide-related conditions.
목차
Abstract
Introduction
Materials and Methods
Results
Discussion
Conclusions
References
참고문헌 (68)
참고문헌 신청
Carvalho FP. Glyphosate, the herbicide that become a nightmare and the Precautionary Principle. International Journal of Environmental Studies 2020;77(6):1012-1023. https://doi.org/10.1080/00207233.2020.1773682
Martins-Gomes C, Silva TL, Andreani T, Silva AM. Glyphosate vs. glyphosate-based herbicides exposure: A review on their toxicity. J Xenobiot 2022;12(1):21–40. https://doi.org/10.3390/jox12010003
Vicini JL, Jensen PK, Young BM, Swarthout JT. Residues of glyphosate in food and dietary exposure. Compr Rev Food Sci Food Saf 2021;20(5):5226-5257. https://doi.org/10.1111/1541-4337.12822
Costas-Ferreira C, Durán R, Faro LR. Toxic effects of glyphosate on the nervous system: a systematic review. Int J Mol Sci 2022;23(9):4605. https://doi.org/10.3390/ijms23094605
von Ehrenstein OS, Ling C, Cui X, Cockburn M, Park AS, Yu F, et al. Prenatal and infant exposure to ambient pesticides and autism spectrum disorder in children: population based case-control study. BMJ 2019;364:l962. https://doi.org/10.1136/bmj.l962
Martins-Gomes C, Silva TL, Andreani T, Silva AM. Glyphosate vs. glyphosate-based herbicides exposure: A review on their toxicity. J Xenobiot 2022;12(1):21–40. https://doi.org/10.3390/jox12010003
Vicini JL, Jensen PK, Young BM, Swarthout JT. Residues of glyphosate in food and dietary exposure. Compr Rev Food Sci Food Saf 2021;20(5):5226-5257. https://doi.org/10.1111/1541-4337.12822
Costas-Ferreira C, Durán R, Faro LR. Toxic effects of glyphosate on the nervous system: a systematic review. Int J Mol Sci 2022;23(9):4605. https://doi.org/10.3390/ijms23094605
von Ehrenstein OS, Ling C, Cui X, Cockburn M, Park AS, Yu F, et al. Prenatal and infant exposure to ambient pesticides and autism spectrum disorder in children: population based case-control study. BMJ 2019;364:l962. https://doi.org/10.1136/bmj.l962
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논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
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