지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 588 - 598 (11page)
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초록· 키워드
오류제보하기
Purpose: Tolfenamic acid (TA), a non-steroidal anti-inflammatory drug, is known to exhibit antitumor effects in various cancers apart from nasopharyngeal cancer (NPC). NPC exhibits high invasiveness, as well as metastatic potential, and patients continue to suffer from residual, recurrent, or metastatic disease even after chemoradiation therapy. Therefore, new treatment strategies are needed for NPC. In this study, we investigated the efficacy and molecular mechanisms of TA in NPC treatment.
Materials and Methods: TA-induced cell death was detected by cell viability assay in the NPC cell lines, HNE1 and HONE1. Wound healing assay, invasion assay, and Western blot analysis were used to evaluate the antitumor effects of TA in NPC cell lines.
Results: Treatment with TA suppressed the migration and invasion of HNE1 and HONE1 cells. Hepatocyte growth factor enhancedthe proliferation, migration, and invasion abilities of NPC cells. This enhancement was successfully inhibited by TA treatment.
Treatment with TA increased phosphorylation of p38, and the inhibition of p38 with SB203580 reversed the cytotoxic, anti-invasive, and anti-migratory effects of TA treatment in NPC cell lines. Moreover, inhibition of p38 also reversed the decrease in expression of Slug that was induced by TA treatment.
Conclusion: In conclusion, the activation of p38 plays a role in mediating TA-induced cytotoxicity and inhibition of invasion and migration via down-regulation of Slug.
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참고문헌 (39)
참고문헌 신청
Oh JK / 2014 / Infection and cancer: global distribution and burden of diseases / Ann Glob Health 80:384~392
Li K / 2014 / Time trends of nasopharyngeal carcinoma in urban Guangzhou over a 12-year period (2000-2011):declines in both incidence and mortality / Asian Pac J Cancer Prev 15:9899~9903
Lee AW / 2005 / Treatment results for nasopharyngeal carcinoma in the modern era: the Hong Kong experience / Int J Radiat Oncol Biol Phys 61:1107~1116
Na’ara S / 2014 / Outcome of patients undergoing salvage surgery for recurrent nasopharyngeal carcinoma: a meta-analysis / Ann Surg Oncol 21:3056~3062
Chan JY / 2015 / Morbidities after maxillary swing nasopharyngectomy for recurrent nasopharyngeal carcinoma / Head Neck 37:487~492
Li K / 2014 / Time trends of nasopharyngeal carcinoma in urban Guangzhou over a 12-year period (2000-2011):declines in both incidence and mortality / Asian Pac J Cancer Prev 15:9899~9903
Lee AW / 2005 / Treatment results for nasopharyngeal carcinoma in the modern era: the Hong Kong experience / Int J Radiat Oncol Biol Phys 61:1107~1116
Na’ara S / 2014 / Outcome of patients undergoing salvage surgery for recurrent nasopharyngeal carcinoma: a meta-analysis / Ann Surg Oncol 21:3056~3062
Chan JY / 2015 / Morbidities after maxillary swing nasopharyngectomy for recurrent nasopharyngeal carcinoma / Head Neck 37:487~492
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