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지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
ICR 마우스를 이용한 소핵시험을 통한 TA 약침의 안전성 평가
Toxicity Evaluation of TA, a Pharmacopuncture Medicine, in an in Vivo Micronucleus Test
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 74 - 80 (7page)
이용수
ICR 마우스를 이용한 소핵시험을 통한 TA 약침의 안전성 평가
초록· 키워드
오류제보하기
Objectives : TA, a polyherbal extract, typically is used for pharmacopuncture therapy on patients with traffic accident-related injuries and musculoskeletal diseases. This study was performed to evaluate the safety of the TA extract, using a micronucleus test. Methods : The dose range and sampling time were first established. An in vivo micronucleus test was then performed to determine the induction of micronuclei in mouse bone marrow cells after a single intramuscular administration of TA to 7-week-old ICR mice (0.2 ml/animal, at 24 hours post-dosing). Results : The incidence of micro-nucleated polychromatic erythrocytes (PCEs) in PCEs in the TA group was similar to that in the negative-control group, while that in the positive-control group was significantly greater. The positive- and negative-control groups did not differ in the ratio of PCEs to total erythrocytes. Conclusions : Our toxicity study indicates that the TA extract does not induce micronucleus formation in mouse bone marrow cells.
목차
등록된 정보가 없습니다.
참고문헌 (16)
참고문헌 신청
Jung C / 2011 / A clinical study of immune pharmacopuncturology / Kyungrak medical publishing co :127~133
Nam SC / 2009 / Immune Pharmacopuncturology / Kyungrak medical publishing co
Kim JH / 2016 / Acupuncture Medicine / Hanmi Medical Publishing Co.
Im WH / 2016 / Anti-inflammatory activities of V, TA and SH Yakchim on LPS-induced nitric oxide and pro-inflammatory cytokines production in Raw 264.7macrophages / Journal of Korea Immuno-Yakchim Society 5:19~25
Chung YH / 2017 / A case report of thoracic pain which was occurred by seat belt with additional TA pharmacopuncture / Journal of Korea Immuno-Yakchim Society 6:39~48
Nam SC / 2009 / Immune Pharmacopuncturology / Kyungrak medical publishing co
Kim JH / 2016 / Acupuncture Medicine / Hanmi Medical Publishing Co.
Im WH / 2016 / Anti-inflammatory activities of V, TA and SH Yakchim on LPS-induced nitric oxide and pro-inflammatory cytokines production in Raw 264.7macrophages / Journal of Korea Immuno-Yakchim Society 5:19~25
Chung YH / 2017 / A case report of thoracic pain which was occurred by seat belt with additional TA pharmacopuncture / Journal of Korea Immuno-Yakchim Society 6:39~48
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