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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 71 - 79 (9page)
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Purpose The purpose of this study is to investigate the role of fibroblast growth factor receptor 4 (FGFR4) polymorphism in esophageal cancer after chemoradiotherapy (CRT).
Materials and Methods Peripheral blood samples from 244 patients treated with CRT for esophageal squamous cell carcinoma were assessed for the role of FGFR4 genotype on treatment response and survival.
Results A total of 94 patients were homozygous for the Gly388 allele, and 110 were heterozygous and 40 homozygous for the Arg388 allele. No significant association was found between the FGFR4 genotype and clinicopathological parameters. However, patients carrying the Gly388 allele showed a better overall response rate than Arg388 carriers (p=0.038). In addition, Gly388 allele patients at an earlier stage showed better overall survival (OS) and progression-free survival than Arg388 carriers. Among these, the Gly388 allele showed sig- nificantly improved OS compared to Arg388 carriers in the lymph node (LN) metastasis group (p=0.042) compared to the no LN metastasis group (p=0.125). However, similar sur- vival outcomes were observed for advanced-stage disease regardless of genotype.
Conclusion This result suggests that the role of FGFR4 Gly388 in treatment outcomes differs according to esophageal cancer stage. It showed a predictive role in the response of esophageal can- cer patients to CRT with a better trend for OS in Gly388 than Arg388 carriers in the early stages. In particular, LN-positive early-stage patients carrying the Gly388 allele showed improved OS compared to those carrying Arg388.
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참고문헌 (24)
참고문헌 신청
Siegel R / 2012 / Cancer statistics, 2012 / CA Cancer J Clin 62:10~29
김대은 / 2013 / Clinical Prognostic Factors for Locally Advanced Esophageal Squamous Carcinoma Treated after Definitive Chemoradiotherapy / Cancer Research and Treatment 45(4):276~284
Shim HJ / 2012 / A phase II study of concurrent chemoradiotherapy with weekly docetaxel and cisplatin in advanced oesophageal cancer / Cancer Chemother Pharmacol 70:683~690
Kelsey CR / 2007 / Paclitaxel-based chemoradiotherapy in the treatment of patients with operable esophageal cancer / Int J Radiat Oncol Biol Phys 69:770~776
Hong TS / 2013 / Targeted therapies with chemoradiation in esophageal cancer: development and future directions / Semin Radiat Oncol 23:31~37
김대은 / 2013 / Clinical Prognostic Factors for Locally Advanced Esophageal Squamous Carcinoma Treated after Definitive Chemoradiotherapy / Cancer Research and Treatment 45(4):276~284
Shim HJ / 2012 / A phase II study of concurrent chemoradiotherapy with weekly docetaxel and cisplatin in advanced oesophageal cancer / Cancer Chemother Pharmacol 70:683~690
Kelsey CR / 2007 / Paclitaxel-based chemoradiotherapy in the treatment of patients with operable esophageal cancer / Int J Radiat Oncol Biol Phys 69:770~776
Hong TS / 2013 / Targeted therapies with chemoradiation in esophageal cancer: development and future directions / Semin Radiat Oncol 23:31~37
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