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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 소화기인터벤션의학회 International Journal of Gastrointestinal Intervention International Journal of Gastrointestinal Intervention Vol.13 No.1
- 발행연도
- 2024.1
- 수록면
- 1 - 7 (7page)
- DOI
- 10.18528/ijgii230072
이용수
초록· 키워드
오류제보하기
Colorectal cancer (CRC) is one of the most prevalent malignancies, and most patients are diagnosed with metastatic disease at first presentation.
However, immunotherapy is particularly useful only in a limited number of patients with mismatch repair-deficient/high microsatellite instability metastatic CRC (mCRC), while most patients have proficient mismatch repair (pMMR)/microsatellite stability (MSS). Currently, many clinical research on immunotherapy in association with tyrosine kinase inhibitors are aiming to modulate the immune microenvironment of pMMR/MSS mCRC and turn “cold tumors” into “hot tumors,” which has not only unanticipated implications, but also good results. Some consequences include that the response may not be selective for metastases. This review summarizes recent studies on potential mechanisms of immunotherapy combined with local therapy (including radiotherapy, ablation, and transcatheter arterial chemoembolization) in the treatment of metastases.
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