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논문 기본 정보

자료유형
학술저널
저자정보
Minna Xiao (Department of Otorhinolaryngology Head and Neck Surgery The Second Xiangya Hospital Central South University) Qinglai Tang (Department of Otorhinolaryngology Head and Neck Surgery The Second Xiangya Hospital Central South University) Shiying Zeng (Department of Otorhinolaryngology Head and Neck Surgery The Second Xiangya Hospital Central South University) Qian Yang (Department of Otorhinolaryngology Head and Neck Surgery The Second Xiangya Hospital Central South University) Xinming Yang (Department of Otorhinolaryngology Head and Neck Surgery The Second Xiangya Hospital Central South University) Xinying Tong (Department of Hemodialysis the Second Xiangya Hospital Central South University) Gangcai Zhu (Department of Otorhinolaryngology Head and Neck Surgery The Second Xiangya Hospital Central South University) Lanjie Lei (State Key Laboratory of Bioelectronics School of Biological Science and Medical Engineering Southeast University) Shisheng Li (Department of Otorhinolaryngology Head and Neck Surgery The Second Xiangya Hospital Central South University)
저널정보
한국생체재료학회 생체재료학회지 생체재료학회지 제27권
발행연도
2023.3
수록면
1,291 - 1,342 (52page)
DOI
https://doi.org/10.1186/s40824-023-00369-8

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Background The immune system interacts with cancer cells in various intricate ways that can protect the individual from overproliferation of cancer cells; however, these interactions can also lead to malignancy. There has been a dramatic increase in the application of cancer immunotherapy in the last decade. However, low immunogenicity, poor specificity, weak presentation efficiency, and off-target side effects still limit its widespread application. Fortunately, advanced biomaterials effectively contribute immunotherapy and play an important role in cancer treatment, making it a research hotspot in the biomedical field. Main body This review discusses immunotherapies and the development of related biomaterials for application in the field. The review first summarizes the various types of tumor immunotherapy applicable in clinical practice as well as their underlying mechanisms. Further, it focuses on the types of biomaterials applied in immunotherapy and related research on metal nanomaterials, silicon nanoparticles, carbon nanotubes, polymer nanoparticles, and cell membrane nanocarriers. Moreover, we introduce the preparation and processing technologies of these biomaterials (liposomes, microspheres, microneedles, and hydrogels) and summarize their mechanisms when applied to tumor immunotherapy. Finally, we discuss future advancements and shortcomings related to the application of biomaterials in tumor immunotherapy. Conclusion Research on biomaterial-based tumor immunotherapy is booming; however, several challenges remain to be overcome to transition from experimental research to clinical application. Biomaterials have been optimized continuously and nanotechnology has achieved continuous progression, ensuring the development of more efficient biomaterials, thereby providing a platform and opportunity for breakthroughs in tumor immunotherapy.

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