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논문 기본 정보

자료유형
학술저널
저자정보
Ji Sung Kim (Chungbuk National University) Yong Guk Kim (Chungbuk National University) Eun Jae Park (Chungbuk National University) Boyeong Kim (Chungbuk National University) Hong Kyung Lee (Chungbuk National University) Jin Tae Hong (Chungbuk National University) Youngsoo Kim (Chungbuk National University) Sang-Bae Han (Chungbuk National University)
저널정보
대한면역학회 Immune Network Immune Network Vol.16 No.2
발행연도
2016.4
수록면
99 - 108 (10page)

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초록· 키워드

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Colorectal cancer is the third leading cancer worldwide. Although incidence and mortality of colorectal cancer are gradually decreasing in the US, patients with metastatic colorectal cancer have poor prognosis with an estimated 5-year survival rate of less than 10%. Over the past decade, advances in combination chemotherapy regimens for colorectal cancer have led to significant improvement in progression-free and overall survival. However, patients with metastatic disease gain little clinical benefit from conventional therapy, which is associated with grade 3∼4 toxicity with negative effects on quality of life. In previous clinical studies, cell-based immunotherapy using dendritic cell vaccines and sentinel lymph node T cell therapy showed promising therapeutic results for metastatic colorectal cancer. In our preclinical and previous clinical studies, cytokine-induced killer (CIK) cells treatment for colorectal cancer showed favorable responses without toxicities. Here, we review current treatment options for colorectal cancer and summarize available clinical studies utilizing cell-based immunotherapy. Based on these studies, we recommend the use CIK cell therapy as a promising therapeutic strategy for patients with metastatic colorectal cancer.

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INTRODUCTION
THE MOLECULAR PATHOGENESIS OF COLORECTAL CANCER
CURRENT TREATMENT OF COLORECTAL CANCER
DENDRITIC CELL THERAPY FOR COLORECTAL CANCER
T CELL THERAPY OF COLORECTAL CANCER
CYTOKINE-INDUCED KILL CELL THERAPY FOR COLORECTAL CANCER
CONCLUSION
REFERENCES

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UCI(KEPA) : I410-ECN-0101-2016-511-002817806