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Novel Therapeutics for Recurrent or Metastatic Gastric Cancer
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전이성 위암의 새로운 치료 요법

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Type
Academic journal
Author
Journal
The Korean Association Of Internal Medicine 대한내과학회지 대한내과학회지 제93권 제1호 KCI Candidated Journals
Published
2018.1
Pages
14 - 24 (11page)

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Novel Therapeutics for Recurrent or Metastatic Gastric Cancer
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Abstract· Keywords

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Despite advances in cancer therapy, gastric cancer has a poor prognosis and high cancer-related mortality. Based on the molecular characteristics of cancer, specific targeted therapies have shown clinical benefits for various tumors. In addition, immunotherapy using immune checkpoint inhibitors has led to a paradigm shift in cancer treatment and shown remarkable results in some solid tumors. Although immunotherapy has been actively applied to gastric cancer, the efficacy is unsatisfactory compared with other solid tumors, such as melanoma and lung cancers. This is because of the complex mechanism of gastric cancer, tumor heterogeneity, heterogeneity among patients, and the absence of appropriate biomarkers to predict response. An effective new cancer treatment strategy that combines targeted therapies and various immunotherapies based on biological markers such as tumor mutation burden and microsatellite instability is urgently needed. Furthermore, customized treatment is necessary to overcome tumor heterogeneity.
#Stomach neoplasms #Therapeutics #Molecular targeted therapies #Immunotherapy

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References (67)

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Parkin DM / 2005 / Global cancer statistics, 2002 / CA Cancer J Clin 55:74~108 Crossref National Cancer Information Center / Cancer incidence google schola Wagner AD / 2006 / Chemotherapy in advanced gastric cancer: a systematic review and meta-analysis based on aggregate data / J Clin Oncol 24:2903~2909 Crossref Bang YJ / 2010 / Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial / Lancet 376:687~697 Crossref Wilke H / 2014 / Ramucirumab plus paclitaxel versus placebo plus paclitaxel in patients with previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (RAINBOW): a double-blind, randomised phase 3 trial / Lancet Oncol 15:1224~1235 Crossref

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