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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2023.12
- 수록면
- 312 - 322 (11page)
- DOI
- 10.20307/nps.2023.29.4.312
이용수
초록· 키워드
오류제보하기
In the present study, bioactivity-guided extraction and isolation of the n-hexane fraction of the fruits of Vietnamese Schisandra sphenanthera led to the isolation of five dibenzocyclooctadiene lignans as gomisin N (1), schisandrin C (2), gomisin H (3), gomisin D (4), and gomisin C (5). All the isolates were tested for their inhibition of NO production in LPS-induced RAW 264.7 cells. Among them, compounds 4 and 5 showed weak inhibition of NO production with IC<SUB>50</SUB> values of 25.0 ± 1.6 and 24.8 ± 2.0 μM, respectively. Compound 1 exhibited NO production inhibition with an IC<SUB>50</SUB> value of 15.8 ± 2.1 μM, meanwhile, schisandrin C (2) showed the most potent inhibition with an IC<SUB>50</SUB> value of 8.5 ± 0.5 μM. In addition, compound 2 had a concentration-dependent inhibitory effect on the protein expression of the inflammatory enzymes iNOS and COX-2. Their physicochemical properties and ADMET data were predicted by in silico, indicating favorable drug-like properties as well as low acute oral toxicity. The results suggest that the fruit of S. sphenanthera and its phytochemical constituents might be used as anti-inflammatory agents.
목차
Abstract
Introduction
Experimental
Result and Discussion
References
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