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논문 기본 정보

자료유형
학술저널
저자정보
Kang, Yun-Mi (Department of Pharmacology, College of Korean Medicine, Sangji University) Jeon, Eun-jin (Department of Pharmacology, College of Korean Medicine, Sangji University) Chung, Kyung-Sook (Catholic Precision Medicine Research Center, College of Medicine, The Catholic University of Korea) Cheon, Se-Yun (Department of Pharmacology, College of Korean Medicine, Sangji University) Park, Jong Hyuk (Institute of Natural Cosmetic Industry for Namwon) Han, Yoo-Chang (Dodan Korean Medicine Clinic) An, Hyo-Jin (Department of Pharmacology, College of Korean Medicine, Sangji University)
저널정보
대한본초학회 대한본초학회지(본초분과학회지) 대한본초학회지 제32권 제2호
발행연도
2017.1
수록면
25 - 32 (8page)

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Objectives : This study was conducted to investigate candidate materials as anti-inflammatory agent from extracts of Korean medicinal plants in Hwaak mountain. Ligustrum obtusifolium (LO) is a Korea medicinal plants that commonly used for robustness and hemostasis. It has been reported that LO has exhibited anti-ischemic, anti-oxidative, anti-hypolipidemic, anti-tumor and hypoglycemic effects. However, LO has not been previously reported to have an anti-inflammatory effect. Therefore, we have evaluated the anti-inflammatory effects of LO and its underlying molecular mechanisms in LPS-induced RAW 264.7 macrophages. Methods : Cell viability was determined by MTT assay in RAW 264.7 macrophages. Nitric Oxide (NO) was measured with Griess reagent and pro-inflammatory cytokines were detected by ELISA in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. Protein expressions of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) and p65 subunit of nuclear $factor-{\kappa}B$ ($NF-{\kappa}B$) were determined by Western blot analysis. Results : Among 15 extracts of Korean medicinal plants tested, Ligustrum obtusifolium (LO) showed the inhibition of NO production without cytotoxicity. LO reduced the expression levels of iNOS and COX-2 proteins in LPS-simulated RAW 264.7 macrophages in dose-dependent manner. Consistent with these data, LO inhibited the productions of $TNF-{\alpha}$, IL-6, and $IL-1{\beta}$ in LPS-simulated RAW 264.7 macrophages. Furthermore, LO attenuated the LPS-induced nuclear translocation of p65 $NF-{\kappa}B$ in RAW 264.7 macrophages involving suppression of $NF-{\kappa}B$ activation. Conclusions : Taken together, these results suggest that the anti-inflammatory effects of LO is associated with regulation of inflammatory mediators via inhibition of $NF-{\kappa}B$ activation in LPS-treated RAW 264.7 macrophages.
#Ligustrum obtusifolium #LO) #lipopolysaccharide #LPS) #nitric oxide #NO) #inducible nitric oxide synthase #iNOS) #cyclooxygenase-2 #COX-2) #nuclear $factor-{kappa}B$ #$NF-{kappa}B$)

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참고문헌 (26)

참고문헌 신청
Guzik, T.J. / 2003 / Nitric oxide and superoxide in inflammation and immune regulation / J Physiol Pharmacol 54(4):469~487 google schola Feng, G.J. / 1999 / Extracellular signal-related kinase (ERK) and p38mitogen-activated protein (MAP) kinases differentially regulate the lipopolysaccharidemediated induction of inducible nitric oxide synthase and IL-12 in macrophages: Leishmania phosphoglycans subvert macrophage IL-12 production by targeting ERK MAP kinase / J Immunol 163(12):6403~6412 google schola Hu, B. / 2014 / Aloe-emodin from rhubarb (Rheum rhabarbarum)inhibits lipopolysaccharide-induced inflammatory responses in RAW264.7 macrophages / J Ethnopharmacol 153(3):846~853 google schola Li, Q. / 2002 / NF-kappaB regulation in the immune system / Nat Rev Immunol 2(10):725~734 google schola Hayden, M.S. / 2014 / Regulation of NFkappaB by TNF family cytokines / Semin Immunol 26(3):253~266 google schola

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